783321-36-8Relevant articles and documents
Phenolic diterpenoid derivatives as anti-influenza a virus agents
Dang, Zhao,Jung, Katherine,Zhu, Lei,Xie, Hua,Lee, Kuo-Hsiung,Chen, Chin-Ho,Huang, Li
supporting information, p. 355 - 358 (2015/03/30)
A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.