78399-79-8

Basic information

• Product Name: 3-Aminobenzoic-d4 Acid
• Synonyms: 3-Aminobenzoic-d4 Acid
• CAS NO: 78399-79-8
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.13598
• Mol File: 78399-79-8.mol

Chemical Properties

• Appearance: /
• Solubility: Methanol
• CAS DataBase Reference: 3-Aminobenzoic-d4 Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminobenzoic-d4 Acid(78399-79-8)
• EPA Substance Registry System: 3-Aminobenzoic-d4 Acid(78399-79-8)

Safety Data

• Hazardous Substances Data: 78399-79-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminobenzoic-d4 Acid is used as a reactant for the preparation of influenza neuraminidase inhibitors, which are essential in the development of antiviral drugs to combat influenza infections.
Used in Biomedical Research:
3-Aminobenzoic-d4 Acid is used as a chemoattractant against Pseudomonas strains, playing a crucial role in studying bacterial chemotaxis and the development of new antimicrobial agents.
Used in Protein Research:
3-Aminobenzoic-d4 Acid is used as an inhibitor of transthyretin amyloid fibril formation, which is important in understanding the molecular mechanisms of amyloid diseases and developing therapeutic strategies to prevent or treat them.
Used in Biochemistry:
3-Aminobenzoic-d4 Acid is used as an inhibitor of the protein chaperone Hsp90, which is involved in the stabilization and folding of various proteins. Studying its interaction with Hsp90 can provide insights into the regulation of protein folding and the development of new therapeutic agents targeting protein misfolding diseases.

Upstream product

• 99-05-8 meta-aminobenzoic acid 
• 78399-78-7 [2,4,5,6-D₄]3-nitrobenzoic acid 

Downstream Products

• 78399-78-7 [2,4,5,6-D₄]3-nitrobenzoic acid 

Relevant articles and documents

Indole ketone compound or its derivatives and their use

The present invention relates to indolone compounds shown by general formula (a) or derivatives thereof, and uses thereof. The technical problem solved by the present invention is to provide indolone compounds or derivatives thereof, and uses thereof. The present invention uses a deuterium-enriched indolone compound obtained from a deuterium-substituted indolone compound. The above-mentioned indolone compounds can simultaneously effect on three key receptor families involved in the process of blood vessel formation, i.e., vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet-derived growth factor receptor (PDGFR), and inhibit the formation of blood vessel, thereby achieving the effect of treating cancers. The above-mentioned deuterium-substituted indolone compounds or derivatives thereof have the advantage of high efficiency as medicaments.

A Single PLP-Dependent Enzyme PctV Catalyzes the Transformation of 3-Dehydroshikimate into 3-Aminobenzoate in the Biosynthesis of Pactamycin

Natural amino donation: A PLP-dependent aminotransferase PctV, encoded in the pactamycin biosynthetic gene cluster, was found to catalyze the formation of 3-aminobenzoate from 3-dehydroshikimate with L-glutamate as the amino donor. The PctV reaction comprises a transamination and two dehydration reactions. This is the first report of a simple 3-ABA synthase in nature.

Hydrogen-deuterium exchange reactions of aromatic compounds and heterocycles by NaBD4-activated rhodium, platinum and palladium catalysts

Conventional thermal and microwave conditions were compared for hydrogen-deuterium (H/D) exchange reactions of aminobenzoic acids catalysed by NaBD4-activated Pd/C or RhCl3 with D2O as the deuterium source. We also investi