78428-92-9Relevant articles and documents
New Synthetic Route for the Preparation of 4-Phenylthio-4-butanolide Derivatives by the Use of the Pummerer Rearrangement
Watanabe, Mikio,Nakamori, Seijin,Hasegawa, Hatsue,Shirai, Kozo,Kumamoto, Takanobu
, p. 817 - 821 (2007/10/02)
The Pummerer rearrangement reaction of 2- or 3-substituted 4-(phenylsulfinyl)butyric acids in the presence of an excess amount of acetic anhydride and a catalytic amount of p-toluenesulfonic acid in refluxing toluene for 1 h afforded 2- or 3-substituted 4-phenylthio-4-butanolide (17a-f).Thermolysis in pyridine of 4-phenylsulfinyl 4-butanolides, which were prepared by oxidation of 17a-f, afforded 2- or 3-substituted 2- or 3-buten-4-olides.