78436-46-1Relevant articles and documents
Synthesis and stability of two indomethacin prodrugs
Chandrasekaran, Shyamala,Al-Ghananeem, Abeer M.,Riggs, Robert M.,Crooks, Peter A.
, p. 1874 - 1879 (2007/10/03)
The purpose of this study was to synthesize and study the in vitro enzymatic and non-enzymatic hydrolysis of indomethacin-TEG ester and amide prodrugs. It was found that the ester conjugate 10 was comparatively stable between pH 3 and 6 (half-life >90 h),
ESTERS OF 1-p-CHLOROBENZOYL-5-METHOXY-2-METHYL-3-INDOLYLACETIC ACID
Fisnerova, Ludmila,Rabek, Vlastimil,Nemecek, Oldrich
, p. 901 - 905 (2007/10/02)
Reactions of imidazolide of 1-p-chlorobenzoyl-5-methoxy-2-methyl-3-indolylacetic acid, prepared from the acid and N,N'-carbonyldiimidazole, with the optically active forms of 2-phenyl-3-hydroxypropane acid and with the inactive forms of p-chloro-, p-isopropyl- and p-isobutyl-2-phenyl-3-hydroxypropane acids gave the corresponding esters.The compounds were tested for antiinflammatory activity.