78574-94-4

Basic information

• Product Name: CYCLOASTRAGENOL
• Synonyms: (3beta,6alpha,16beta,20R,24S) 20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Astramembrangenin;Cyclosieversigenin;CYCLOASTRAGENOL(SH);Cyclogalegenol;Cycloastragenol, 98%, from Astragalus membranaceus Bunge
• CAS NO: 78574-94-4
• Molecular Formula: C₃₀H₅₀O₅
• Molecular Weight: 490.72
• Mol File: 78574-94-4.mol
• Article Data: 31

Chemical Properties

• Melting Point: 241.0 to 245.0 °C
• Boiling Point: 617.174 °C at 760 mmHg
• Flash Point: 327.055 °C
• Appearance: /
• Density: 1.2 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.57±0.29(Predicted)
• CAS DataBase Reference: CYCLOASTRAGENOL(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOASTRAGENOL(78574-94-4)
• EPA Substance Registry System: CYCLOASTRAGENOL(78574-94-4)

Safety Data

• RTECS: GX8265000
• Hazardous Substances Data: 78574-94-4(Hazardous Substances Data)

Usage

General Description

Cycloastragenol is a naturally occurring compound found in the roots of various plants, most notably the Astragalus membranaceus species. This chemical has been the subject of scientific attention due to its potential role in activating telomerase, an enzyme critical for cellular health and longevity. Telomerase is involved in protecting and sometimes extending the length of telomeres, which are parts of chromosomes that shorten with age and can contribute to cellular senescence or aging. Due to these potentially anti-aging properties, Cycloastragenol is often marketed as a dietary supplement for enhancing immune function and promoting overall health. However, more research is needed to definitively establish its effectiveness and safety for these purposes.

Upstream product

• 84687-46-7 (3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside] 
• 83207-58-3 astragaloside IV 
• 86764-12-7 cyclosieversigenin 6-O-β-D-glucopyranoside 
• 86541-80-2 cyclosieversigenin 3,6-diacetate 
• 83207-58-3 cyclosieversioside F 
• 84687-44-5 astragaloside V 
• 84687-42-3 astragaloside III 
• 142735-27-1 Cycloaraloside F 
• 134563-28-3 cycloaraloside E 
• 135101-62-1 cyclocarposide 
• 101858-42-8 cyclosieversioside E 
• 88192-84-1 askenoside B 
• 84680-75-1 (3β,6α,16β,20R,24S)-3-[(2,3-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside 
• 84676-89-1 (3b,6a,16b,20R,24S)-3-((2-O-acetyl-beta-D-xylopyranosyl)oxy)-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside 

Downstream Products

• 84687-42-3 astragaloside III 
• 1255151-96-2 2-(L)-amino-3-phenyl-propionic acid 6α,16β-dihydroxy-17-[5-(1-hydroxy-1-methyl-ethyl)-2-methyl-tetrahydrofuran-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthren-3α-yl ester hydrochloride 
• 1255152-17-0 2-(L)-amino-3-phenyl-propionic acid 3β,16β-dihydroxy-17-[5-(1-hydroxy-1-methyl-ethyl)-2-methyl-tetrahydro-furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthren-6α-yl ester hydrochloride 
• 1255152-16-9 C₄₄H₆₇NO₈ 
• 1255151-95-1 C₄₄H₆₇NO₈ 
• 1255151-99-5 C₃₇H₅₄O₆ 
• 11026-01-0 20(S),24(R)-epoxylanost-9(11)-ene-3β,6α,16β,25-tetraol 
• 86541-79-9 astragenol 

Relevant articles and documents

The use of two-phase acid hydrolysis method of preparing ring [...] (by machine translation)

The invention belongs to the field of pharmaceutical chemicals, in particular to the use of double-phase acid hydrolysis method of preparing ring [...], including astragaloside as raw materials, and the organic phase and the acid solution of the two-phase acid aqueous solution mixing, reaction, after-treatment, to obtain the ring [...]; wherein organic phase immiscible with water or slightly soluble, ring [...] in the organic phase is greater than the solubility of the aqueous phase. This invention utilizes the double-phase acid hydrolysis method for preparing ring [...], making acid is hydrolyzed to generate ring [...] distribution in the organic phase, thereby avoiding the ring [...] in violent acid aqueous phase into the shortcoming of the [...], effectively protect the stability of the ring [...], [...] greatly improves the yield of the ring, and the step is simple, low cost, and is suitable for industrial production; through the standstill, layered, extraction, silica gel column chromatography separation to obtain high-purity [...]. (by machine translation)

Triterpene glycosides from astragalus. Structure of cyclolehmanoside C from A. lehmannianus

The structure of a new cycloartane triterpene glycoside, cyclolehmanoside C, that was isolated from the aerial part of Astragalus lehmannianus Bunge (Leguminosae) was established as 20R,24S-epoxycycloartane-3β,6α, 16β,24-tetraol 3-O-[β-D-glucopyranosyl(1→2)]- β-D-glucopyranoside-25-O-β-D-glucopyranoside.

Compositions and Methods for Increasing Telomerase Activity

The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.