78708-10-8

Basic information

• Product Name: (E)-3-Dimethylamino-2-formyl-N-(4-nitro-phenyl)-acrylamide
• Synonyms: (E)-3-Dimethylamino-2-formyl-N-(4-nitro-phenyl)-acrylamide
• CAS NO: 78708-10-8
• Molecular Weight: 263.253
• Mol File: 78708-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-Dimethylamino-2-formyl-N-(4-nitro-phenyl)-acrylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-Dimethylamino-2-formyl-N-(4-nitro-phenyl)-acrylamide(78708-10-8)
• EPA Substance Registry System: (E)-3-Dimethylamino-2-formyl-N-(4-nitro-phenyl)-acrylamide(78708-10-8)

Safety Data

• Hazardous Substances Data: 78708-10-8(Hazardous Substances Data)

Upstream product

• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 5. The Synthesis of 2-Chloroquinoline-3-carbaldehydes

Acetanilides are converted into 2-chloroquinoline-3-carbaldehydes in good yield by the action of Vilsmeier's reagent in phosphoryl chloride solution.The reaction is shown to involve successive conversion of the acetanilide into an imidoyl chloride and then an N-(α-chlorovinyl)aniline.The latter enamine is diformylated at its β-position and subsequently cyclised to the chloroquinolinecarbaldehyde.The diformylated intermediates may be isolated in several cases and separately cyclised with polyphosphoric acid.