78963-60-7

Basic information

• Product Name: (3R,4R)-4-acetoxy-3-<(S)-1-(tert-butyldimethylsilyloxy)ethyl>-2-azetidinone
• Synonyms: (3R,4R)-4-acetoxy-3-<(S)-1-(tert-butyldimethylsilyloxy)ethyl>-2-azetidinone
• CAS NO: 78963-60-7
• Molecular Weight: 287.431
• Mol File: 78963-60-7.mol
• Article Data: 55

Chemical Properties

• CAS DataBase Reference: (3R,4R)-4-acetoxy-3-<(S)-1-(tert-butyldimethylsilyloxy)ethyl>-2-azetidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R)-4-acetoxy-3-<(S)-1-(tert-butyldimethylsilyloxy)ethyl>-2-azetidinone(78963-60-7)
• EPA Substance Registry System: (3R,4R)-4-acetoxy-3-<(S)-1-(tert-butyldimethylsilyloxy)ethyl>-2-azetidinone(78963-60-7)

Safety Data

• Hazardous Substances Data: 78963-60-7(Hazardous Substances Data)

Upstream product

• 79-21-0 peracetic acid 
• 109323-90-2 (1'R,3S)-3-<1'-<(tert-butyldimethylsilyl)oxy>ethyl>azetidin-2-one 
• 123-62-6 propionic acid anhydride 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 85253-97-0 (2S,3S)-3-[1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidine-2-carboxylic acid 
• 85253-97-0 (3S,4S)-3-<(R)-1'-(dimethyl-t-butylsilyloxy)ethyl>-4-oxoazetidine-2-carboxylic acid 
• 78902-67-7 (3R,4R)-4-acetoxy-3-<1-(tert-butyldimethylsilyloxy)ethyl>-1-(1-methoxycarbonil-2-methyl-1-propenyl)-2-azetidinone 
• 76855-68-0 2-{(2R,3R)-2-Acetoxy-3-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid benzyl ester 
• 111619-17-1 {(R)-2-Acetoxy-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid methyl ester 
• 111619-17-1 {(S)-2-Acetoxy-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid methyl ester 
• 106399-62-6 (1'R,3S,4S)-3-(1'-(tert-butyldimethylsilyloxy)ethyl)-4-formyl-1-(4'-methoxyphenyl)-2-azetidinone 
• 97363-07-0 (2S,3S)-3-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid 
• 111969-68-7 (3S,4S)-3-<(R)-1'-hydroxyethyl>-1-dimethyl-t-butylsilyl-4-dimethyl-t-butylsilyloxycarbonylazetidin-2-one 

Downstream Products

• 135297-22-2 (3S,4R)-3-<(R)-1-tert-butyldimethylsilyloxy-ethyl>-4-<(2'S,6'S)-6'-methoxy-1-oxo-cyclohex-2'-yl>-azetidin-2-one 
• 175891-54-0 (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-((1S,3S)-3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one 
• 592528-33-1 (3S)-3-[(1R)-1-(tert-butyldimethylsilanyloxy)ethyl]-4-[(1Z)-2-oxo-2-phenylethylidene]azetidin-2-one 
• 950187-51-6 3-(S)-[1-(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(R)-((1S,3R)-3-butoxy-2-oxo-cyclohexyl)-azetidin-2-one 
• 950187-52-7 3-(S)-[1-(R)-(tert-butyldimethylsilyloxy)-ethyl]-4-(R)-((1R,3S)-3-butoxy-2-oxo-cyclohexyl)-azetidin-2-one 
• 135297-27-7 C₂₀H₃₇NO₄Si 
• 225219-80-7 3S-<1R-(tert-butyldimethylsilanyloxy)ethyl>-4S-(5-oxo-2R-phenylsulfanyl-2,5-dihydrofuran-2-yl)azetidin-2-one 
• 1026319-51-6 3-[1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-[2-oxo-2-(1-phenethyl-1H-[1,2,3]triazol-4-yl)-ethyl]-azetidin-2-one 
• 189072-85-3 (3R,4S)-3-[(1R)-1-tert-butyldimethylsiloxyethyl]-4-(3-tert-butyldimethylsiloxy-3-phenyl-2-oxopropyl)azetidin-2-one 

Relevant articles and documents

Preparation method of azetidinone compound and preparation method 4 - acyloxy-azetidinone compound

The invention provides a preparation method of a azetidinone compound and a preparation method of 4 - acyloxy-azetidinone compound. The preparation method comprises the following steps S1, an epoxy amide compound reacts with I alkali reagents to form a ring reaction, and first 1st reaction systems are obtained. Step S2: The first reaction system is subjected to hydroxyl protection reaction with a raw material including a silanization reagent and a nitrogen-containing basic organic matter to obtain second reaction systems. In step S3, second reaction system and second base reagent are subjected to isomerization reaction to obtain the azetidinone compound, wherein the epoxy amide compound has the structure shown VI, the separation process of the isomer product of the structure shown II and formula III IV is avoided, and the selectivity and yield of the azetidinone compound are improved.

Method for removing P-methoxyphenyl protecting group on amide group

The invention provides a method for removing p-methoxyphenyl protecting groups on amide groups. The method comprises the steps of sequentially performing ozonation reaction and quenching treatment on a substrate and ozone in the presence of an organic solvent to obtain an oxidation intermediate, wherein an amide group in the substrate is protected by a p-methoxyphenyl group. The oxidation intermediate is subjected to a reduction reaction with carbon monoxide or a mixed gas containing carbon monoxide to remove p-methoxyphenyl. After the substrate and the ozone are subjected to ozonation reaction, the product system of the ozonation reaction is quenched, and then the quenched oxidized intermediate and carbon monoxide are subjected to a reduction reaction to remove p-methoxyphenyl groups to obtain the required amide organic matters. To the method for removing the P-methoxyphenyl protecting group on the amide group, thiourea is not needed, so that the whole process does not generate sulfur-containing wastewater, the cost is lower, and the method is more environmentally friendly.

Preparation method of penem antibiotic intermediate 4 - acetoxy azacyclobutanone (by machine translation)

The invention discloses a preparation method of penem antibiotic intermediate 4 - acetoxy azacyclobutanone (4 - AA), and specifically discloses a preparation method of 4 - acetoxyazacyclobutanone (4 - AA) in an organic solvent under the action of a metal catalyst and an oxidant, and has the characteristics of being economical and efficient, small in environmental pollution and high in yield 4 - 4 - AA. (by machine translation)