Welcome to LookChem.com Sign In|Join Free

Cas Database

79-22-1

79-22-1

Identification

  • Product Name:Methyl chloroformate

  • CAS Number: 79-22-1

  • EINECS:201-187-3

  • Molecular Weight:94.4976

  • Molecular Formula: C2H3ClO2

  • HS Code:2915.13

  • Mol File:79-22-1.mol

Synonyms:Formicacid, chloro-, methyl ester (6CI,8CI);Chlorocarbonic acid methyl ester;Chloroformic acid methyl ester;Methoxycarbonyl chloride;Methylcarbonochloridate;Methyl chlorocarbonate;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):FlammableF, VeryT+

  • Hazard Codes:F,T+

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapourH302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H330 Fatal if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Refer for medical attention . Methyl chloroformate is highly toxic upon inhalation and upon ingestion. A concentration of 1 mg/liter (190 ppm) has been lethal in 10 minutes. It is corrosive and irritating to skin. (EPA, 1998)

  • Fire-fighting measures: Suitable extinguishing media Water, dry chem, foam, carbon dioxide. Cool exposed containers with water. This chemical is very dangerous when exposed to heat sources, sparks, flame, or oxidizers. It will react with water or steam to produce toxic and corrosive fumes. Vapors may travel to a source of ignition and flash back. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Toxic fumes of phosgene are produced when the material is heated to decomposition. Heat or steam should be avoided. (EPA, 1998) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Fireproof. Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room.OWING TO THE FACT THAT THESE CMPD DECOMPOSE EASILY, STORAGE CONTAINERS SHOULD BE VENTED. /CHLOROFORMATES/

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:MethylChloroformate
  • Packaging:10g
  • Price:$ 150
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:MethylChloroformate
  • Packaging:10 g
  • Price:$ 650
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:MethylChloroformate
  • Packaging:1 g
  • Price:$ 610
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Chemenu
  • Product Description:methylcarbonochloridate 95%+
  • Packaging:1000g
  • Price:$ 38
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 35 Articles be found

-

Bailey,Di Pietro

, p. 179 (1978)

-

Synthesis of N-trifluoromethyl amides from carboxylic acids

Flavell, Robert R.,Liu, Jianbo,Parker, Matthew F. L.,Toste, F. Dean,Wang, Sinan,Wilson, David M.

supporting information, p. 2245 - 2255 (2021/08/12)

Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged as important functional groups frequently found in pharmaceutical compounds. To date, there is no strategy for synthesizing N-trifluoromethyl amides from abundant organic carboxylic acid derivatives, which are ideal starting materials in amide synthesis. Here, we report the synthesis of N-trifluoromethyl amides from carboxylic acid halides and esters under mild conditions via isothiocyanates in the presence of silver fluoride at room temperature. Through this strategy, isothiocyanates are desulfurized with AgF, and then the formed derivative is acylated to afford N-trifluoromethyl amides, including previously inaccessible structures. This method shows broad scope, provides a platform for rapidly generating N-trifluoromethyl amides by virtue of the diversity and availability of both reaction partners, and should find application in the modification of advanced intermediates.

Photolytic Activation of Late-Transition-Metal-Carbon Bonds and Their Reactivity toward Oxygen

Britovsek, George J. P.,De Aguirre, Adiran,Ho, Sarah K. Y.,Lam, Francis Y. T.,Maseras, Feliu,White, Andrew J. P.

supporting information, p. 4077 - 4091 (2021/12/17)

The photolytic activation of palladium(II) and platinum(II) complexes [M(BPI)(R)] (R = alkyl, aryl) featuring the 1,3-bis(2-pyridylimino)isoindole (BPI) ligand has been investigated in various solvents. In the absence of oxygen, the formation of chloro complexes [M(BPI)Cl] is observed in chlorinated solvents, most likely due to the photolytic degradation of the solvent and formation of HCl. The reactivity of the complexes toward oxygen has been studied both experimentally and computationally. Excitation by UV irradiation (365 nm) of the metal complexes [Pt(BPI)Me] and [Pd(BPI)Me] leads to distortion of the square-planar coordination geometry in the excited triplet state and a change in the electronic structure of the complexes that allows the interaction with oxygen. TD-DFT computational studies suggest that, in the case of palladium, the Pd(III) superoxide intermediate [Pd(BPI)(κ1-O2)Me] is formed and, in the case of platinum, the Pt(IV) peroxide intermediate [Pt(BPI)(κ2-O2)Me]. For alkyl complexes where metal-carbon bonds are sufficiently weak, the photoactivation leads to the insertion of oxygen into the metal-carbon bond to generate alkylperoxo complexes: for example [Pd(BPI)OOMe], which has been isolated and structurally characterized. For stronger M-C(aryl) bonds, the reaction of [Pt(BPI)Ph] with O2 and light results in a Pt(IV) complex, tentatively assigned as the peroxo complex [Pt(BPI)(κ2-O2)Ph], which in chlorinated solvents reacts further to give [Pt(BPI)Cl2Ph], which has been isolated and characterized by scXRD. In addition to the facilitation of oxygen insertion reactions, UV irradiation can also affect the reactivity of other components in the reaction mixture, such as the solvent or other reaction products, which can result in further reactions. Labeling studies using [Pt(BPI)(CD3)] in chloroform have shown that photolytic reactions with oxygen involve degradation of the solvent.

Photo-on-Demand Synthesis of Chloroformates with a Chloroform Solution Containing an Alcohol and Its One-Pot Conversion to Carbonates and Carbamates

Liang, Fengying,Suzuki, Yuto,Tsuda, Akihiko,Yanai, Masaki

, (2020/04/21)

Chloroformates are key reagents for synthesizing carbonates and carbamates. The present study reports a novel photo-on-demand in situ synthesis of chloroformates with a CHCl3 solution containing a primary alkyl alcohol. It further allowed the one-pot synthesis of carbonates and carbamates through subsequent addition of alcohols or amines, respectively.

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as new antitubercular agents with potent in vitro and in vivo efficacy

Cheng, Ya-Juan,Liu, Zhi-Yong,Liang, Hua-Ju,Fang, Cui-Ting,Zhang, Niu-Niu,Zhang, Tian-Yu,Yan, Ming

, (2019/06/07)

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625-6.25 μg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against cell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection model via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class of new antitubercular agents with good potential.

Hepatitis C virus inhibitors, and pharmaceutical compositions and application thereof

-

Paragraph 0088; 0092; 0094; 0095, (2017/07/22)

The invention provides hepatitis C virus inhibitors, and pharmaceutical compositions and an application thereof, wherein the hepatitis C virus inhibitors are compounds represented by the formula (I), or crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof. The compounds have better inhibitory activity of a hepatitis C virus protein NS5A, have better pharmacodynamic/pharmacokinetic properties, have good applicability and high safety, can be used for preparing drugs for treatment of hepatitis C virus infection, and have good prospects for market development.

Process route upstream and downstream products

Process route

methyl chloroformate
79-22-1

methyl chloroformate

carbonochloridic acid, butyl ester
592-34-7

carbonochloridic acid, butyl ester

Conditions
Conditions Yield
methanol
67-56-1

methanol

bis(trichloromethyl) oxalate
98020-90-7

bis(trichloromethyl) oxalate

Dimethyl oxalate
553-90-2

Dimethyl oxalate

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
trichloromethyl trichloroacetate
6135-29-1

trichloromethyl trichloroacetate

tributyltin methoxide
1067-52-3

tributyltin methoxide

Methyl trichloroacetate
598-99-2

Methyl trichloroacetate

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
methanol
67-56-1

methanol

chlorocarbonic acid pentachloroethyl ester
97925-35-4

chlorocarbonic acid pentachloroethyl ester

Methyl trichloroacetate
598-99-2

Methyl trichloroacetate

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
methanol
67-56-1

methanol

formic acid
64-18-6

formic acid

Methyl formate
107-31-3

Methyl formate

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
With chloroform-d1; oxygen; for 16h; under 750.075 Torr; UV-irradiation;
methanol
67-56-1

methanol

methyl nitrite
624-91-9

methyl nitrite

carbon monoxide
201230-82-2

carbon monoxide

methyl chloroformate
79-22-1

methyl chloroformate

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

Conditions
Conditions Yield
With hydrogenchloride; nitrogen(II) oxide; aluminum oxide; palladium dichloride; at 60 ℃; Product distribution; Mechanism; other reagents;
methanol
67-56-1

methanol

phosgene
75-44-5

phosgene

methyl chloroformate
79-22-1

methyl chloroformate

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

Conditions
Conditions Yield
methanol
67-56-1

methanol

methyl 1,1,1-trichloromethyl carbonate
101970-86-9

methyl 1,1,1-trichloromethyl carbonate

methyl chloroformate
79-22-1

methyl chloroformate

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

Conditions
Conditions Yield
mit ueberschuessigem Methanol nur Dimethylcarbonat entsteht;
methanol
67-56-1

methanol

phosgene
75-44-5

phosgene

methylene chloride
74-87-3

methylene chloride

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
Darst.;
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

Dimethoxymethane
109-87-5

Dimethoxymethane

dichloromethane
75-09-2

dichloromethane

Methyl formate
107-31-3

Methyl formate

methyl chloroformate
79-22-1

methyl chloroformate

Conditions
Conditions Yield
With chlorine; palladium dichloride; at 30 - 130 ℃; under 760 Torr; Product distribution; Rate constant; Mechanism; var. conc. of reagents, other catalyst, also in the presence of methyl nitrite and NO;

Global suppliers and manufacturers

Global( 2) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 79-22-1
Post Buying Request Now
close
Remarks: The blank with*must be completed