790-04-5

Basic information

• Product Name: 4-Thiazolidinone, 3-phenyl-2-(phenylimino)-
• CAS NO: 790-04-5
• Molecular Formula: C15H12N2OS
• Molecular Weight: 268.339
• Mol File: 790-04-5.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 4-Thiazolidinone, 3-phenyl-2-(phenylimino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinone, 3-phenyl-2-(phenylimino)-(790-04-5)
• EPA Substance Registry System: 4-Thiazolidinone, 3-phenyl-2-(phenylimino)-(790-04-5)

Safety Data

• Hazardous Substances Data: 790-04-5(Hazardous Substances Data)

Upstream product

• 68-11-1 mercaptoacetic acid 
• 5416-30-8 N,N'-diphenyl-S-methyl isothiourea 
• 3898-08-6 1,1-diphenylthiourea 
• 79-08-3 bromoacetic acid 
• 103-72-0 phenyl isothiocyanate 
• 105-36-2 ethyl bromoacetate 
• 62-53-3 aniline 
• 79-04-9 chloroacetyl chloride 
• 102-08-9 N,N-diphenylthiourea 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 75-15-0 carbon disulfide 
• 79-11-8 chloroacetic acid 
• 96-32-2 bromoacetic acid methyl ester 
• 81852-22-4 ethyl cyano<thio>acetate 

Downstream Products

• 328268-80-0 TTS₂₉ 
• 1082953-77-2 (2Z,5Z)-5-(3,4-dimethoxybenzylidene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 1082953-74-9 (2Z,5Z)-5-(2,2-dimethylpropylidene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 1082953-73-8 (2Z,5Z)-5-(4-(methylthio)benzylidene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 1082953-81-8 (2Z,5Z)-5-(cyclohexylmethylene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 114597-82-9 4-(4-oxo-3-phenyl-2-phenyliminothiazolidin-5-ylidenemethyl)benzoic acid 
• 328268-69-5 [4-(4-oxo-3-phenyl-2-phenyliminothiazolidin-5-ylidenemethyl)phenoxy]acetic acid 
• 352325-43-0 5-(5-chloro-2-oxoindolin-3-ylidene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 
• 1010-53-3 3-phenyl-2,4-thiazolidinedione 
• 67637-16-5 5-(2-nitro-benzylidene)-3-phenyl-2-phenylimino-thiazolidin-4-one 
• 114597-81-8 2-(4-oxo-3-phenyl-2-phenylimino-thiazolidin-5-ylidenemethyl)-benzoic acid 
• 182881-16-9 5-cinnamylidene-3-phenyl-2-phenylimino-thiazolidin-4-one 
• 110662-88-9 (2Z,5Z)-5-(2-hydroxybenzylidene)-3-phenyl-2-(phenylimino)thiazolidin-4-one 

Relevant articles and documents

Synthesis of 2-iminothiazolidin-4-ones using guanine functionalized SBA-16 as a solid base catalyst

The first example of a one-pot three-component tandem annulation approach is described for the synthesis of 2-iminothiazolidin-4-ones by the reaction of aromatic/aliphatic amines, aryl isothiocyanates, and ethyl bromoacetate, catalysed by guanine-functionalized SBA-16, [SBA-16@G], as an efficient and recyclable heterogeneous solid base catalyst. The methodology is simple and offers a broad-substrate scope under mild reaction conditions.

Visible Light-Promoted Three-Component Tandem Annulation for the Synthesis of 2-Iminothiazolidin-4-ones

Described is a visible light-promoted three-component tandem annulation of amines, aryl/alkyl isothiocyanates, and α-bromoesters to form 2-iminothiazolidin-4-ones in the absence of metal and photocatalyst at room temperature. This [1 + 2 + 2] cyclization strategy involves visible light-promoted C-S/C-N bond formation and features a powerful approach to the synthesis of 2-iminothiazolidin-4-ones with broad substrate scope, excellent functional group tolerance, mild reaction conditions, step-economy, and simple operation, which also has potential applications in the pharmaceutical industry. UV-vis spectroscopy indicates that an in situ-generated H-bonding electron donor-acceptor (EDA) complex probably acts as the photocatalyst, facilitating the reaction process.

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.