793-55-5Relevant articles and documents
Direct Conversion of 13β-Alkylgonatetraenes into 13β-Alkylgon-4-en-3-ones
Bijoy, Panicker,Ramachandran, Uma,Rao, G. S. R. Subba
, p. 2331 - 2334 (2007/10/02)
Birch reduction of 8,9-didehydroestradiol-17β 3-methyl ether 1 or 9(11)-didehydroestradiol-17β 3 methyl ether 2 followed by acid hydrolysis results in a mixture of 19-nortestosterone 8 and 19-nor-9β,10α-testosterone 9 in varying amounts.However, reduction of their acetates with sodium or lithium, tert-butyl alcohol in liquid ammonia and in the presence of aniline affords exclusively 19-nortestosterone.Similarly, 18α-homo-19-nortestosterone 12 is prepared from the acetate of 18α-homoestradiol-17β 3 methyl ether, 10.
Synthesis of 13-alkyl-gon-4-ones
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, (2008/06/13)
The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.