79574-71-3

Basic information

• Product Name: Methanone, (2-fluoro-3-pyridinyl)phenyl-
• CAS NO: 79574-71-3
• Molecular Formula: C12H8FNO
• Molecular Weight: 201.2
• Mol File: 79574-71-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (2-fluoro-3-pyridinyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-fluoro-3-pyridinyl)phenyl-(79574-71-3)
• EPA Substance Registry System: Methanone, (2-fluoro-3-pyridinyl)phenyl-(79574-71-3)

Safety Data

• Hazardous Substances Data: 79574-71-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 17763-67-6 Phenyl triflate 
• 155533-81-6 2-fluoro-3-(tributylstannanyl)pyridine 
• 13939-06-5 molybdenum hexacarbonyl 
• 372-48-5 2-fluoropyridine 
• 98-88-4 benzoyl chloride 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 79574-62-2 2-fluoro-3-(phenyl-1-hydroxymethyl)pyridine 

Downstream Products

• 3810-10-4 2-amino-3-benzoylpyridine 
• 1125674-20-5 3-phenylfuro[2,3-b]pyridine-2-carboxylic acid diethylamide 
• 1125674-24-9 4-(3-phenylfuro[2,3-b]pyridine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1125674-22-7 (morpholin-4-yl)(3-phenylfuro[2,3-b]pyridin-2-yl)methanone 
• 1125674-11-4 3-phenylfuro[2,3-b]pyridine-2-carboxylic acid 
• 1125674-09-0 (3-benzoylpyridin-2-yloxy)acetic acid 
• 1125674-00-1 3-phenylfuro[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 1125674-26-1 phenyl(3-phenylfuro[2,3-b]pyridin-2-yl)methanone 
• 164657-31-2 C₁₄H₉NO₂S 
• 514182-30-0 3-phenylthieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 178549-05-8 3-benzoyl-2-propylaminopyridine 
• 83584-44-5 2-Amino-6-methyl-3-pyridyl-phenyl-keton 
• 79574-77-9 3-benzoyl-N-methylpyridin-2-amine 
• 79574-81-5 phenyl[2-(phenylamino)pyridin-3-yl]methanone 

Relevant articles and documents

Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type i positive allosteric modulators of α7 nicotinic acetylcholine receptors

A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be type I positive allosteric modulators (PAMs) of human α7 nAChRs expressed in Xenopus ooctyes. Structure-activity relationship (SAR) studies resulted in the identification of compound 7v as a potent and efficacious type I PAM with maximum modulation of a nicotine EC 5 response of 1200% and EC50 = 0.18 μM. Compound 7z was active in reversing the effect of scopolamine in the novel object recognition (NOR) paradigm with a minimum effective ip dose of 1.0 mg/kg (2.7 μmol/kg). This effect was blocked by the selective α7 nAChR antagonist methyllycaconitine (MLA). These compounds are potent type I positive allosteric modulators of α7 nAChRs that may have therapeutic value in restoring impaired sensory gating and cognitive deficits in schizophrenia and Alzheimer's disease.

Convenient Stille carbonylative cross-couplings using molybdenum hexacarbonyl

Palladium catalysis was used in Stille-type carbonylative cross-couplings employing Mo(CO)6 as the carbon monoxide source. Robust and convenient transformations were carried out in closed vessels at 100 °C, providing a set of diaryl ketones in good yields. Aryl triflates and bromides were used as coupling partners with aryl stannanes. Inclusion of the Mo(CO)6 destabilizing agent DBU made this protocol operationally simple and suppressed side-product formation.

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): Pyridodiazepine amines

An SAR study of an HTS screening hit generated a series of pyridodiazepine amines as potent inhibitors of Helicobacter pylori glutamate racemase (MurI) showing highly selective anti-H. pylori activity, marked improved solubility, and reduced plasma protei