799557-86-1 Usage
Uses
Used in Pharmaceutical Industry:
Pyrimidine, 5-bromo-2-(trifluoromethyl)is used as a key intermediate in the synthesis of pyrimidinone compounds. These compounds have been found to possess Lp-PLA2 inhibitory properties, which are important for the development of drugs targeting various inflammatory and cardiovascular diseases.
In the preparation of pyrimidinone compounds as Lp-PLA2 inhibitors, Pyrimidine, 5-bromo-2-(trifluoromethyl)plays a crucial role in the formation of the final product. The unique structural features of Pyrimidine, 5-bromo-2-(trifluoromethyl)-, such as the bromine and trifluoromethyl groups, contribute to the overall activity and selectivity of the resulting pyrimidinone compounds. This makes Pyrimidine, 5-bromo-2-(trifluoromethyl)a valuable component in the development of novel therapeutic agents for the treatment of various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 799557-86-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,9,5,5 and 7 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 799557-86:
(8*7)+(7*9)+(6*9)+(5*5)+(4*5)+(3*7)+(2*8)+(1*6)=261
261 % 10 = 1
So 799557-86-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H2BrF3N2/c6-3-1-10-4(11-2-3)5(7,8)9/h1-2H
799557-86-1Relevant articles and documents
PROCESS FOR PREPARING 1-ARYLSULFONYL-PYRROLIDINE-2-CARBOXAMIDE TRANSIENT RECEPTOR POTENTIAL CHANNEL ANTAGONIST COMPOUNDS AND CRYSTALLINE FORMS THEREOF
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Paragraph 0450; 0452-0454, (2019/09/12)
The invention relates generally to methods of preparing 1-arylsulfonyl-pyrrolidine-2-carboxamide Transient Receptor Potential channel antagonist compounds of the following structure (I): (I) The invention further relates to solvate and co-crystal polymorphs of crystalline formula (I), and methods of preparation thereof.
