79965-75-6

Basic information

• Product Name: 2-methyl-4-(4-nitro-phenyl)-oxazole
• Synonyms: 2-methyl-4-(4-nitro-phenyl)-oxazole
• CAS NO: 79965-75-6
• Molecular Weight: 204.185
• Mol File: 79965-75-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-methyl-4-(4-nitro-phenyl)-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-(4-nitro-phenyl)-oxazole(79965-75-6)
• EPA Substance Registry System: 2-methyl-4-(4-nitro-phenyl)-oxazole(79965-75-6)

Safety Data

• Hazardous Substances Data: 79965-75-6(Hazardous Substances Data)

Upstream product

• 20662-90-2 2-methyl-4-phenyloxazole 
• 60-35-5 acetamide 
• 99-81-0 4-Nitrophenacyl bromide 
• 10342-64-0 p-nitroacetophenone oxime 
• 267877-41-8 2-acetyl-3-(4-nitrophenyl)isoxazol-5(2H)-one 

Downstream Products

• 181870-63-3 1-[4-(2-methyl-4-oxazolyl)phenyl]-2(1H,3H)-imidazolone 
• 325989-14-8 C₁₁H₁₂N₄O₂ 
• 325989-08-0 [4-(2-methyl-oxazol-4-yl)-phenyl]-carbamic acid phenyl ester 
• 325989-20-6 1-(2,2-diethoxy-ethyl)-3-[4-(2-methyl-oxazol-4-yl)-phenyl]-urea 
• 62-23-7 4-nitro-benzoic acid 
• 79965-86-9 2-Methyl-5-nitro-4-(4-nitro-phenyl)-oxazole 
• 942920-47-0 5-bromo-2-methyl-4-(4-nitrophenyl)-1,3-oxazole 
• 216059-89-1 4-(2-methyl-oxazol-4-yl)-aniline 

Relevant articles and documents

PdII-Catalyzed Regio- and Enantioselective Oxidative C?H/C?H Cross-Coupling Reaction between Ferrocenes and Azoles

Asymmetric C?H bond functionalization reaction is one of the most efficient and straightforward methods for the synthesis of optically active molecules. Herein we disclose an asymmetric C?H/C?H cross-coupling reaction of ferrocenes with azoles such as oxazoles and thiazoles. Palladium(II)/monoprotected amino acid (MPAA) catalytic system which exhibits excellent reactivity and regioselectivity for oxazoles and thiazoles. This method offers a powerful strategy for constructing planar chiral ferrocenes. Mechanistic studies suggest that the C?H bond cleavage of azoles is likely proceeding through a SEAr process and may not be a turnover limiting step.

High-temperature rearrangements of 2-acylisoxazol-5(2H)-ones and related oxazoles

2-Acyl-3-arylisoxazol-5(2H)-ones give 2-alkyl(aryl)-4-aryloxazoles in good yields at 540°C under flash vacuum pyrolysis conditions, but at higher temperatures the expected oxazoles are accompanied by increasing amounts of isomeric 2,5-disubstituted oxazoles, as well as anilides and decomposition products of the 2,4-disubstituted oxazole. The rearrangement mechanisms have been studied by the use of 13C labelled substrates and p-substituted 3-arylisoxazolones. The 2,5-disubstituted oxazoles are considered to arise from 1H-azirines, and the anilides from the nitrone ketene isomer of the acylisoxazolone.