80029-43-2

Basic information

• Product Name: 1-Hydroxybenzotriazole hydrate
• Synonyms: 1-HYDROXYBENZOTRIAZOLE N-HYDRATE;1-HYDROXYBENZOTRIAZOL MONOHYDRATE;1,2,3-BENZOTRIAZOL-1-OL MONOHYDRATE;1-HYDROXY-1,2,3-BENZOTRIAZOLE (HOBT);HOBt hydrate;1-Hydroxybenzotriazole hydrate;HOBT monohydrate (1 Hydroxybenzotriazole monohydrate);1,2,3-Benzotriazol-1-ol HOBt
• CAS NO: 80029-43-2
• Molecular Formula: 2C₆H₅N₃O*H₂O
• Molecular Weight: 153.14
• EINECS: 219-989-7
• Mol File: 80029-43-2.mol

Chemical Properties

• Melting Point: 155-158 °C(lit.)
• Boiling Point: 344.6 °C at 760 mmHg
• Flash Point: 162.2 °C
• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMF: 100 mg/mL, clear
• CAS DataBase Reference: 1-Hydroxybenzotriazole hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Hydroxybenzotriazole hydrate(80029-43-2)
• EPA Substance Registry System: 1-Hydroxybenzotriazole hydrate(80029-43-2)

Safety Data

• Hazard Codes: F
• Statements: 5-11
• Safety Statements: 15-16-35
• RIDADR: UN 3380 4.1/PG 1
• RTECS: DM1288000
• F: 4.10-8
• HazardClass: 4.1
• PackingGroup: Ⅰ
• Hazardous Substances Data: 80029-43-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Hydroxybenzotriazole hydrate is used as a coupling agent in organic synthesis for enhancing the efficiency and yield of peptide synthesis, ester, and amide formation. It is commonly combined with other reagents such as carbodiimides and N-hydroxy succinimide to promote amide bond formation.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 1-Hydroxybenzotriazole hydrate is utilized as a key component in the synthesis of various drugs, facilitating the formation of crucial chemical bonds and improving the overall yield of the synthesis process.
Used in Research:
1-Hydroxybenzotriazole hydrate is employed in research laboratories for studying the mechanisms of peptide coupling reactions and exploring new methods to improve the synthesis of complex organic molecules. Its stability and solubility properties make it an ideal candidate for various research applications in organic chemistry.

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