80357-37-5

Basic information

• Product Name: 2,6-dimethyl-N,1-bis(2-methylphenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
• Synonyms: 3-pyridinecarboxamide, 1,4-dihydro-2,6-dimethyl-N,1-bis(2-methylphenyl)-4-oxo-
• CAS NO: 80357-37-5
• Molecular Formula: C₂₂H₂₂N₂O₂
• Molecular Weight: 346.4223
• Mol File: 80357-37-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 524.2°C at 760 mmHg
• Flash Point: 270.8°C
• Density: 1.195g/cm³
• Vapor Pressure: 4.4E-11mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2,6-dimethyl-N,1-bis(2-methylphenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-N,1-bis(2-methylphenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide(80357-37-5)
• EPA Substance Registry System: 2,6-dimethyl-N,1-bis(2-methylphenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide(80357-37-5)

Safety Data

• Hazardous Substances Data: 80357-37-5(Hazardous Substances Data)

Usage

Function

Antagonist of the N-methyl-D-aspartate (NMDA) receptor

Selectivity

Selective antagonist

Receptor Type

NMDA receptor

Role in Brain Function

Modulation of synaptic plasticity and memory function

Therapeutic Applications

Treatment of neurological disorders such as epilepsy, stroke, and neurodegenerative diseases

Neuroprotective Properties

Prevents neuronal damage under pathological conditions

Research Tool

Valuable for studying mechanisms of brain function and neurologic diseases.

Upstream product

• 93-68-5 3-oxo-N-o-tolylbutanamide 
• 102-01-2 N-phenylacetoacetamide 

Downstream Products

• 1523153-61-8 5-bromo-2,6-dimethyl-4-oxo-N,1-di-o-tolyl-1,4-dihydropyridine-3-carboxamide 
• 1523153-79-8 N-(4-bromo-2-methylphenyl)-2,6-dimethyl-4-oxo-1-(o-tolyl)-1,4-dihydropyridine-3-carboxamide 
• 1523153-83-4 5-bromo-N-(4-bromo-2-methylphenyl)-2,6-dimethyl-4-oxo-1-(o-tolyl)-1,4-dihydropyridine-3-carboxamide 

Relevant articles and documents

An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide

A self-condensation cyclization reaction mediated by phosphorus pentoxide (P2O5) and catalyzed by zinc bromide (ZnBr2) is presented for the synthesis of polysubstituted 4-pyridones and 2-pyridones from β-keto amides. A var

Preparation and Antiinflammatory Activity of 2- and 4-Pyridones

Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.