80357-45-5

Basic information

• Product Name: 5-bromo-2,6-dimethyl-4-oxo-N,1-diphenyl-1,4-dihydropyridine-3-carboxamide
• Synonyms: 3-pyridinecarboxamide, 5-bromo-1,4-dihydro-2,6-dimethyl-4-oxo-N,1-diphenyl-
• CAS NO: 80357-45-5
• Molecular Formula: C₂₀H₁₇BrN₂O₂
• Molecular Weight: 397.2652
• Mol File: 80357-45-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 535°C at 760 mmHg
• Flash Point: 277.4°C
• Density: 1.473g/cm³
• Vapor Pressure: 1.6E-11mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 5-bromo-2,6-dimethyl-4-oxo-N,1-diphenyl-1,4-dihydropyridine-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2,6-dimethyl-4-oxo-N,1-diphenyl-1,4-dihydropyridine-3-carboxamide(80357-45-5)
• EPA Substance Registry System: 5-bromo-2,6-dimethyl-4-oxo-N,1-diphenyl-1,4-dihydropyridine-3-carboxamide(80357-45-5)

Safety Data

• Hazardous Substances Data: 80357-45-5(Hazardous Substances Data)

Upstream product

• 65190-89-8 1,4-dihydro-2,6-dimethyl-N,1-diphenyl-4-oxo-3-pyridinecarboxamide 
• 24572-69-8 β-anilinocrotonoanilide 

Relevant articles and documents

Preparation and Antiinflammatory Activity of 2- and 4-Pyridones

Several N-alkyl- and N-arylacetoamides have been self-condensed to form pyridones.N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoamides give 4-pyridones.In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in rats.While the 2-pyridones were not active, 9 of 17 4-pyridones tested were active, and one compound (4g) had antiinflammatory efficacy in a dose-response assay (ED50 values).Most compounds were considered nontoxic by determination of approximate LD50 values in mice by a standard multidimensional observational assay.