80881-75-0

Basic information

• Product Name: Acetamide, N-[3-[3-(4-chlorophenyl)-1-oxo-2-propenyl]-4-hydroxyphenyl]-
• CAS NO: 80881-75-0
• Molecular Formula: C17H14ClNO3
• Molecular Weight: 315.756
• Mol File: 80881-75-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[3-[3-(4-chlorophenyl)-1-oxo-2-propenyl]-4-hydroxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[3-[3-(4-chlorophenyl)-1-oxo-2-propenyl]-4-hydroxyphenyl]-(80881-75-0)
• EPA Substance Registry System: Acetamide, N-[3-[3-(4-chlorophenyl)-1-oxo-2-propenyl]-4-hydroxyphenyl]-(80881-75-0)

Safety Data

• Hazardous Substances Data: 80881-75-0(Hazardous Substances Data)

Upstream product

• 103-90-2 4-acetaminophenol 
• 7298-67-1 5-acetamido-2-hydroxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 285138-20-7 N-[2-(4-chloro-phenyl)-3-methoxy-4-oxo-4H-chromen-6-yl]-acetamide 
• 285138-17-2 N-[2-(4-chloro-phenyl)-3-hydroxy-4-oxo-4H-chromen-6-yl]-acetamide 

Relevant articles and documents

Selected novel 5’-amino-2’-hydroxy-1, 3-diaryl-2- propen-1-ones arrest cell cycle of HCT-116 in G0/G1 phase

A series of 5’-amino-2’-hydroxy-1,3-diaryl-2-propen-1-ones (AC1-AC15) were synthesized by Claisen-Schmidt condensation of 5'-acetamido-2’-hydroxy acetophenone with various substituted aromatic aldehydes. The syn- thesized compounds were characterized by FTIR, 1H NMR and mass spectrometry and evaluated for their selec- tive cytotoxicity using MTT assay on two cancer cell lines namely breast cancer cell line (MCF-7), colon cancer cell line (HCT-116) and one normal kidney epithelial cell line (Vero). Among the tested compounds, AC-10 showed maximum cytotoxic effect on MCF-7 cell line with IC50 value 74.7 ± 3.5 μM. On HCT-116 cells, AC-13 exhibited maximum cytotoxicity with IC50 value 42.1 ± 4.0 μM followed by AC-14 and AC-10 with IC50 values 62 ± 2.3 μM and 95.4 ± 1.7 μM respectively. All tested compounds were found to be safe on Vero cell line with IC50 value more than 200 μM. Based on their highest efficacy on HCT-116, AC-10, AC-13 and AC-14 were selected for mechanistic study on this cell line by evaluating changes nucleomorphological characteristics using acridine orange-ethidium bromide (AOEB) dual stain and by analyzing cell cycle with flow cytometry using propidium iodide stain. In AOEB staining, all three tested compounds showed significant (p 0/G1 phase and by AC-13 in G0/G1 and G2/M phase. The study reflected the potential of AC-10, AC-13 and AC-14 to be the lead molecules for further optimization.