80971-33-1

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine
• CAS NO: 80971-33-1
• Molecular Weight: 658.867
• Mol File: 80971-33-1.mol
• Article Data: 39

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine(80971-33-1)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine(80971-33-1)

Safety Data

• Hazardous Substances Data: 80971-33-1(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-89-5 thymidine 
• 226943-40-4 5'-O-tetrahydropyranyl-3'-O-(tert-butyldimethylsilyl)thymidine 
• 40733-27-5 3'-O-(t-butyldimethylsilyl)thymidine 
• 150884-13-2 O⁴-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 151072-22-9 C₇₈H₁₀₀N₆O₁₂Si₂ 
• 150884-11-0 N⁽³⁾-Allyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)thymidine 
• 80971-34-2 3'-O-t-butyldimethylsilyl-5'-O-dimethoxytrityl-1-[5-methyl-4-triazolylpyrimidin-2(1H)-onyl]-β-D-2'-deoxyriboside 
• 50-89-5 thymidine 
• 182810-26-0 C₂₇H₃₀ClN₄O₁₁P 
• 182810-28-2 C₄₈H₄₈ClN₄O₁₃P 

Relevant articles and documents

Silylation of 5'-O-DMT-2'-deoxynucleosides using dibenzo [18] crown-6-and PTC

3'-O-silylated derivatives of 5'-O-DMT-2'-deoxynucleoside (2) were synthesized in high yield by reaction of 5'-O-DMT-2'-deoxynucleosides (1) with tert-butyl dimethylsilylchloride using sodium hydride, benzyltriethylammonium chloride [TEBA] and a catalytic

Enantiodivergent Formation of C-P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides

Phosphorus Incorporation (PI, abbreviated Π) reagents for the modular, scalable, and stereospecific synthesis of chiral phosphines and methylphosphonate nucleotides are reported. Synthesized from trans-limonene oxide, this reagent class displays an unexpected reactivity profile and enables access to chemical space distinct from that of the Phosphorus-Sulfur Incorporation reagents previously disclosed. Here, the adaptable phosphorus(V) scaffold enables sequential addition of carbon nucleophiles to produce a variety of enantiopure C-P building blocks. Addition of three carbon nucleophiles to Π, followed by stereospecific reduction, affords useful P-chiral phosphines; introduction instead of a single methyl group reveals the first stereospecific synthesis of methylphosphonate oligonucleotide precursors. While both Π enantiomers are available, only one isomer is required - the order of nucleophile addition controls the absolute stereochemistry of the final product through a unique enantiodivergent design.

REACTIVE, LIPOPHILIC NUCLEOSIDE BUILDING BLOCKS FOR THE SYNTHESIS OF HYDROPHOBIC NUCLEIC ACIDS

The present invention relates to a method for the isolation and/or identification of known or unknown sequences of nucleic acids (target sequences) optionally marked with reporter groups by base specific hybridation with complementary sequences using nucleolipids. The nucleolipids are prepared by lipophilizing nucleosides of formula (Ia) wherein Q represents a group having a substituted tetrahydrofuran ring and Bas represents a group having one or more heterocyclic rings having one or more heterocyclic nitrogen atoms.