Welcome to LookChem.com Sign In|Join Free

Cas Database

81-24-3

81-24-3

Identification

  • Product Name:Ethanesulfonic acid,2-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-

  • CAS Number: 81-24-3

  • EINECS:201-336-2

  • Molecular Weight:515.712

  • Molecular Formula: C26H45 N O7 S

  • HS Code:

  • Mol File:81-24-3.mol

Synonyms:Taurine,N-choloyl- (8CI); Cholane, ethanesulfonic acid deriv.; 3a,7a,12a-Trihydroxy-5b-cholanic acid-24-taurine; Cholaic acid; Cholic acid taurine conjugate;Cholyltaurine; N-Choloyltaurine; NSC 25505; Taurocholic acid

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:TaurocholicAcid
  • Packaging:250mg
  • Price:$ 295
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:TaurocholicAcid
  • Packaging:100mg
  • Price:$ 145
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:TAUROCHOLIC ACID 95.00%
  • Packaging:5MG
  • Price:$ 505.2
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 4 Articles be found

Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1-protease inhibitory activity

Kagedahl, Matts,Swaan, Peter W.,Redemann, Carl T.,Tang, Mary,Craik, Charles S.,Szoka Jr., Francis C.,ie, Svein

, p. 176 - 180 (1997)

Purpose. To investigate the ability of the human intestinal bile acid transporter to transport cholic acid conjugates with potential HIV-1 protease inhibitory activity. Methods. Cholic acid was conjugated at the 24 position of the sterol nucleus with various amino acids and amino acid analogs. The CaCo2 cell line was used as a model to investigate the interaction of these bile acid conjugates with the human intestinal bile acid transporter. Interaction between the carrier and the conjugates was quantified by inhibition of taurocholic acid transport and confirmed by transport of radiolabelled conjugates in this cell line. Results. The highest interaction with the transporter, as quantified by inhibition of taurocholic acid transport, occurred when a single negative charge was present around the 24 to 29 region of the sterol nucleus. A second negative charge or a positive charge significantly reduced the interaction. Transport of radiolabelled cholyl-L-Lys-ε-tBOC ester and cholyl-D-Asp-β-benzyl ester was inhibited by taurocholic acid. Of all tested compounds, only cholyl-D-Asp-β-benzyl ester showed modest HIV-1 protease inhibitory activity with an IC50 of 125 μM Conclusions. Cholic acid-amino acid conjugates with appropriate stereochemistry are recognized and transported by the human bile acid transporter and show modest HIV-1 protease inhibitory activity. Transport of these conjugates by the bile acid carrier is influenced by charge and hydrophobicity around the 24 position of the sterol nucleus.

OPHTHALMIC COMPOSITIONS COMPRISING dDC

-

, (2010/04/23)

A composition comprising dDC and a polymer, wherein the composition is an aqueous liquid with a viscosity which increases upon contact with a surface of an eye is disclosed herein. An aqueous composition comprising a therapeutically effective concentration of dDC, wherein the concentration of dDC is less than 1% is also disclosed. An eye drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 μg is also disclosed. A method comprising administering an effective amount of dDC topically to an eye of a person suffering from viral conjunctivitis a viral infection, wherein less than 300 μL of dDC is administered to said eye is also disclosed. A kit comprising a composition and a dispenser, wherein said dispenser dispenses a drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 μg is also disclosed.

Chemical modifications of bile acids under high-intensity ultrasound or microwave irradiation

Cravotto, Giancarlo,Boffa, Luisa,Turello, Marta,Parenti, Massimo,Barge, Alessandro

, p. 77 - 83 (2007/10/03)

High-intensity ultrasound (HIU) and microwave (MW) irradiation, having emerged as effective promoters of organic reactions, were exploited for the synthesis of bile acids derivatives. Esterification, amidation, hydrolysis, oxidation, and reduction were investigated. Compared to conventional methods, both techniques proved much more efficient, increasing product yields and dramatically cutting down reaction times. Scaled-up studies are now under way.

An improved procedure for the synthesis of glycine and taurine conjugates of bile acids

Tserng,Hachey,Klein

, p. 404 - 407 (2007/10/06)

Glycine and taurine conjugates of 5β cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of choly[1,2 13C2]glycine is described.

Process route upstream and downstream products

Process route

cholic acid
81-25-4

cholic acid

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; water; for 0.166667h; microwave irradiation;
58%
10-undecenyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate
850210-60-5

10-undecenyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 0.1 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
octacos-10-enyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate
850210-62-7

octacos-10-enyl 7α,12α,3α-trihydroxy-5β-cholan-24-oate

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 94 percent / KOH / methanol; H2O / 0.13 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate
15073-99-1,47676-48-2,101230-69-7,101230-70-0

ethyl (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 97 percent / KOH / methanol; H2O / 0.07 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
methyl cholate
1448-36-8

methyl cholate

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 99 percent / KOH / methanol; H2O / 0.07 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester
122752-67-4

(3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oic acid 1,1-dimethylethyl ester

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 95 percent / KOH / methanol; H2O / 0.07 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
benzyl 3α,7α,12α-trihydroxyl-5β-cholestane-24-carboxylic ester
105730-97-0

benzyl 3α,7α,12α-trihydroxyl-5β-cholestane-24-carboxylic ester

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 96 percent / KOH / methanol; H2O / 0.07 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
octanyl cholate
211448-18-9

octanyl cholate

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 98 percent / KOH / methanol; H2O / 0.08 h / microwave irradiation
2: 58 percent / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride / DMAP / tetrahydrofuran; H2O / 0.17 h / microwave irradiation
With potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In tetrahydrofuran; methanol; water;
cholic acid hydrazide
80948-49-8

cholic acid hydrazide

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: aqueous hydrochloric acid; aqueous sodium nitrite solution
2: aq. NaOH solution
With hydrogenchloride; sodium hydroxide; sodium nitrite;
3α,7α,12α-trihydroxy-5β-cholanoyl-(24)-azide
40248-73-5

3α,7α,12α-trihydroxy-5β-cholanoyl-(24)-azide

Taurocholic acid
81-24-3

Taurocholic acid

Conditions
Conditions Yield
With sodium hydroxide;

Global suppliers and manufacturers

Global( 33) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86217390
  • Emails:info@gihichem.com
  • Main Products:66
  • Country:China (Mainland)
  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 81-24-3
Post Buying Request Now
close
Remarks: The blank with*must be completed