811794-19-1

Basic information

• Product Name: N,N-bis(4-methoxybenzyl)-2-[3-(4-cyano-3-trifluoromethylphenyl)-4-imino-5,5-dimethyl-2-thioxoimidazolidin-1-yl]ethanesulfonamide
• Synonyms: N,N-bis(4-methoxybenzyl)-2-[3-(4-cyano-3-trifluoromethylphenyl)-4-imino-5,5-dimethyl-2-thioxoimidazolidin-1-yl]ethanesulfonamide
• CAS NO: 811794-19-1
• Molecular Weight: 659.753
• Mol File: 811794-19-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-bis(4-methoxybenzyl)-2-[3-(4-cyano-3-trifluoromethylphenyl)-4-imino-5,5-dimethyl-2-thioxoimidazolidin-1-yl]ethanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(4-methoxybenzyl)-2-[3-(4-cyano-3-trifluoromethylphenyl)-4-imino-5,5-dimethyl-2-thioxoimidazolidin-1-yl]ethanesulfonamide(811794-19-1)
• EPA Substance Registry System: N,N-bis(4-methoxybenzyl)-2-[3-(4-cyano-3-trifluoromethylphenyl)-4-imino-5,5-dimethyl-2-thioxoimidazolidin-1-yl]ethanesulfonamide(811794-19-1)

Safety Data

• Hazardous Substances Data: 811794-19-1(Hazardous Substances Data)

Upstream product

• 811794-17-9 N,N-bis(4-methoxybenzyl)-2-[(cyanodimethylmethyl)amino]ethanesulfonamide 
• 143782-23-4 4-isothiocyanato 2-(trifluoromethyl)benzonitrile 

Downstream Products

• 811794-20-4 2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]ethanesulfonic acid bis-(4-methoxybenzyl)amide 

Relevant articles and documents

Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists

A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of hormone refractory prostate cancer. CH4933468 (32d) with a sulfonamide side chain not only exhibited antagonistic activity with no agonistic activity in the reporter gene assay but also inhibited the growth of bicalutamide-resistant cell lines. This compound also inhibited tumor growth of the LNCaP xenograft in mice dose-dependently.

IMIDAZOLIDINE DERIVATIVE

The present invention provides a compound represented by formula (I): wherein n is an integer selected from 1 to 20, and R1 and R2, which may be the same or different, each represent a hydrogen atom or a linear or branched C1/s