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Cas Database

814-49-3

814-49-3

Identification

  • Product Name:Phosphorochloridicacid, diethyl ester

  • CAS Number: 814-49-3

  • EINECS:212-396-4

  • Molecular Weight:172.548

  • Molecular Formula: C4H10ClO3P

  • HS Code:29199000

  • Mol File:814-49-3.mol

Synonyms:Ethylphosphorochloridate (6CI);Chlorodiethoxyphosphine oxide;Chlorodiethylphosphate;Diethoxyphosphorus oxychloride;Diethoxyphosphorylchloride;Diethyl chlorophosphonate;Diethylphosphochloridate;Diethyl phosphochoridate;Diethyl phosphorochloride;Diethylphosphoric acid chloride;Ethylphosphorochloridate (Cl(EtO)2PO);Ethyl phosphorochloridate (EtO)2ClPO;NSC43770;O,O-Diethyl chloridophosphate;O,O-Diethyl phosphorochloridate;Phosphoric acid chloride diethyl ester;

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Safety information and MSDS view more

  • Pictogram(s):VeryT+

  • Hazard Codes:T+

  • Signal Word:Danger

  • Hazard Statement:H300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. This material is a cholinesterase inhibitor. It has high oral and very high dermal toxicity. It is a skin irritant. It is also toxic by inhalation. (EPA, 1998) Absorption, Distribution and ExcretionSkin absorption.

  • Fire-fighting measures: Suitable extinguishing media Use the following procedures for combustible liquids. Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. For massive fire in cargo area, use unmanned hose holder or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. This material is combustible. Methods for combustible liquids are as follows. Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. (EPA, 1998) Emits very toxic fumes of chloride and phosphorus oxides when heated to decomposition. (EPA, 1998) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:Diethyl chlorophosphate
  • Packaging:50g
  • Price:$ 230
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  • Manufacture/Brand:TRC
  • Product Description:Diethyl chlorophosphate
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Diethyl chlorophosphate 97%
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Diethyl chlorophosphate 97%
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Diethyl chlorophosphate
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Diethyl chlorophosphate, 97+%
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:Diethyl chlorophosphate, 97+%
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Relevant articles and documentsAll total 63 Articles be found

The synthesis and reactions of dialkyl fluoroalkyl phosphates

Timperley, Christopher M.,Morton, Ian J.,Waters, Matthew J.,Yarwood, Jason L.

, p. 95 - 100 (1999)

Dimethyl and diethyl fluoroalkyl phosphates were prepared from (1) a dialkyl phosphite with a fluoroalcohol, triethylamine and carbon tetrachloride, (2) a dialkyl chlorophosphate with a fluoroalcohol and triethylamine, and (3) a dialkyl chlorophosphate with the sodium salt of a fluoroalcohol. Dimethyl and diethyl (2,2,2-trifluoroethyl) phosphates reacted with bromotrimethylsilane (TMSBr) in chloroform to give two products with loss of alkyl bromide. The major product was an alkyl (trifluoroethyl) trimethylsilyl phosphate, RO(TMSO)P(O)OCH2CF3 and the minor product was a bis(trimethylsilyl) trifluoroethyl phosphate, (TMSO)2P(O)OCH2CF3. The mechanism presumably involves initial attack of an alkoxy oxygen atom on the silicon atom of bromotrimethylsilane. Diethyl (2,2,2-trifluoroethyl) phosphate is resistant to chlorination. It did not react with oxalyl or thionyl chloride in chloroform under prolonged reflux. Unlike triethyl phosphate, it did not react with phosphorus oxychloride in chloroform under reflux.

Extraction of hexachloroplatinate from hydrochloric acid solutions with phosphorylated hexane-1,6-diyl polymers

Hahn, Simone,Holdt, Hans-Jürgen

, p. 878 - 888 (2012)

A series of diols (diethylene glycol, triethylene glycol, butane-1,4-diol and hexane-1,6-diol) were immobilized onto Merrifield resin and subsequently phosphorylated with dialkyl chlorophosphate (alkyl = Me, Et, Bu). The resins bearing hexane-1,6-diyl groups exhibited very good extraction abilities in regard to precious metal chloro complexes like platinum(IV), palladium(II) and rhodium(III). In batch experiments, more than 98% of Pt(IV) is extracted even when the metal and the hydrochloric acid concentration is enhanced significantly. Elution can be achieved with a solution of 0.5 mol L-1 thiourea in 0.1 mol L-1 hydrochloric acid. In the presence of other noble metals, platinum(IV) is preferentially bound. The extraction yield decreases in slightly acidic solution in the following order: Pt(IV) ≈ Pd(II) > Rh(III) and changes with increasing hydrochloric acid concentration to Pt(IV) > Pd(II) ? Rh(III). At different ratios of metal and acid, the temperature has nearly no influence on the platinum extraction. On slightly acidic media, the extraction of rhodium decreases by 30% when the temperature is increased from 10°C to 40°C. When the acid and metal concentration is enhanced, the palladium extraction decreases by 7-9%, depending on the resin.

Organophosphorus derivatives containing piperazine dithiosemicarbazones as chemotherapeutants against fungal pathogens of sugarcane

Chandra, Ruchi,Pandey,Sengupta

, p. 2181 - 2184 (2005)

Five novel organophosphorus derivatives have been synthesized by the reactions of O,O-diethylchlorophosphate with piperazine dithiosemicarbazones. The derivatives have been characterized on the basis of analyses and spectral (IR, 1H NMR) data. Fungicidal activities of these derivatives against Colletotrichum falcatum, Fusarium oxysporum, and Curvularia pallescence have been evaluated. The screening results have been correlated with the structural features of the tested compounds. Organophosphorus derivatives containing 1,4-bis(4-chlorobenzaldehyde)piperazine dithiosemicarbazone and 1,4-bis(4-methoxybenzaldehyde)piperazine dithiosemicarbazone proved to be more active than some prevalent commercial synthetic fungicides.

Tunable Redox Potential Photocatalyst: Aggregates of 2,3-Dicyanopyrazino Phenanthrene Derivatives for the Visible-Light-Induced α-Allylation of Amines

Bao, Ming,He, Min,Wang, Yi,Yu, Xiaoqiang

, p. 14720 - 14731 (2021/11/16)

This work highlights the tunable redox potential of 6,11-dibromo-2,3-dicyanopyrazinophenanthrene (DCPP3) aggregates, which can be formed through physical π-πstacking interactions with other DCPP3 monomers. Electrochemical and scanning electron microscopy showed that the reduction potential of [DCPP3]n aggregates could be increased by decreasing their size. The size of [DCPP3]n aggregates could be regulated by controlling the concentration of DCPP3 in an organic solvent. As such, a fundamental understanding of this tunable redox potential is essential for developing new materials for photocatalytic applications. The [DCPP3]n aggregates as a visible-light photocatalyst in combination with Pd catalysts in the visible-light-induced α-allylation of amines were used. This [DCPP3]n photocatalyst exhibits excellent photo- and electrochemical properties, including a remarkable visible-light absorption, long excited-state lifetime (16.6 μs), good triplet quantum yield (0.538), and high reduction potential (Ered([DCPP3]n/[DCPP3]n-) > -1.8 V vs SCE).

Ene-Yne Metathesis of Allylphosphonates and Allylphosphates: Synthesis of Phosphorus-Containing 1,3-Dienes

Rohde, Laurence N.,Wild, Thérèse H.,Diver, Steven T.

, p. 1371 - 1384 (2021/02/05)

A variety of ene-yne cross metathesis reactions were performed using unsaturated phosphonate and phosphate reagents, affording the corresponding phosphorylated 1,3-diene products in good to excellent yields. These difficult ene-yne metatheses employed a Grubbs catalyst bearing a cyclic amino alkyl carbene ligand. A variety of terminal alkynes of varying substitution underwent the reaction, and different phosphorus-containing alkenes were found to give the conjugated diene products in high yields. The resulting dienes were further transformed by Horner-type Wittig reactions and a Diels-Alder cycloaddition.

Quinoline derivatives, and preparation method and use thereof

-

Paragraph 0232-0234, (2019/10/17)

The invention belongs to the technical field of insecticides and acaricides, and particularly relates to quinoline derivatives, and a preparation method and a use thereof, and concretely provides compounds represented by formula (I), and stereoisomers, racemates, tautomers, isotope labels, oxynitrides, pharmaceutically acceptable salts or solvates thereof. The compounds of the formula (I) have an excellent activity against various pests and pest mites in the agricultural field or other fields. The compounds can achieve an excellent control effect at a very low dosage, so the compounds can be used to prepare insecticides and/or acaricides. In addition, the preparation steps of the compounds of the invention are simple, and the product yield is high, so that the compounds have a good application prospect.

Phosphate ionic liquids as well as synthetic method and application thereof

-

Paragraph 0027; 0028, (2018/05/16)

The invention discloses phosphate ionic liquids, a synthetic method thereof and an application as a lithium extraction agent. According to the method, the functional ionic liquids containing phosphamide groups are prepared from dibutyl phosphite, trichloroisocyanuric acid, N,N'-dimethylethanediamine and potassium hexafluorophosphate taken as raw materials through phosphoryl chlorination reaction,amidation with amine, salt forming reaction and exchange reaction. Compared with the prior art, the ionic liquids and the synthetic method thereof have the characteristics that operation is simple, industrial popularization and application are facilitated and the like, and have important application values.

Eco-Friendly and Industrially Scalable Synthesis of the Sex Pheromone of Lobesia botrana. Important Progress for the Eco-Protection of Vineyard

Cahiez, Gérard,Guerret, Olivier,Moyeux, Alban,Dufour, Samuel,Lefevre, Nicolas

supporting information, p. 1542 - 1546 (2017/10/25)

A one-pot synthesis of the pheromone of Lobesia botrana is described. The procedure allows an efficient and economical access to this product which is used for the protection of vineyards.

Process route upstream and downstream products

Process route

ethanol
64-17-5

ethanol

phosphorus pentachloride
10026-13-8,874483-75-7

phosphorus pentachloride

chloroethane
75-00-3

chloroethane

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

ethyl phosphodichloridite
1498-51-7

ethyl phosphodichloridite

Conditions
Conditions Yield
at -10 ℃;
diethyl ether
60-29-7,927820-24-4

diethyl ether

ethanol
64-17-5

ethanol

phosphorus pentachloride
10026-13-8,874483-75-7

phosphorus pentachloride

chloroethane
75-00-3

chloroethane

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

ethyl phosphodichloridite
1498-51-7

ethyl phosphodichloridite

Conditions
Conditions Yield
at -10 ℃;
tetrachloromethane
56-23-5

tetrachloromethane

diethyl trimethylsilyl phosphite
13716-45-5

diethyl trimethylsilyl phosphite

1,1,3,3-tetramethyl-1,3-disiletane
1627-98-1

1,1,3,3-tetramethyl-1,3-disiletane

chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

diethyl (trichloromethyl)phosphonate
866-23-9

diethyl (trichloromethyl)phosphonate

chloroform
67-66-3,8013-54-5

chloroform

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

Conditions
Conditions Yield
at 45 - 55 ℃; for 3h; Product distribution;
19.7%
59.7%
30.86 % Chromat.
3.71 % Chromat.
tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

triethyl phosphite
122-52-1

triethyl phosphite

triethyl phosphate
78-40-0

triethyl phosphate

tertiary butyl chloride
507-20-0

tertiary butyl chloride

Ethyl tert-butyl ether
637-92-3

Ethyl tert-butyl ether

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

3-Chloro-2-methylpropene
563-47-3

3-Chloro-2-methylpropene

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

Conditions
Conditions Yield
In dichloromethane; at 20 ℃; Rate constant;
tert-butylhypochlorite
507-40-4

tert-butylhypochlorite

diethyl (tert-butyl) phosphite
14540-22-8

diethyl (tert-butyl) phosphite

(2-methyl-2-propyl) diethyl phosphate
13232-08-1

(2-methyl-2-propyl) diethyl phosphate

tertiary butyl chloride
507-20-0

tertiary butyl chloride

2,2'-oxybis(2-methyl-propane)
6163-66-2

2,2'-oxybis(2-methyl-propane)

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

Conditions
Conditions Yield
In dichloromethane; at 20 ℃; Mechanism;
styryltrichlorophosphonium hexachlorophosphorate
40969-10-6

styryltrichlorophosphonium hexachlorophosphorate

diethyl phosphorylchloridite
589-57-1

diethyl phosphorylchloridite

styrylphosphonic dichloride
4708-07-0

styrylphosphonic dichloride

dichloro(styryl)phosphine
17391-53-6

dichloro(styryl)phosphine

β-phenyl-β-chloroethyldichlorophosphine
66441-50-7

β-phenyl-β-chloroethyldichlorophosphine

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

ethyl phosphodichloridite
1498-51-7

ethyl phosphodichloridite

Conditions
Conditions Yield
With Diethyl phosphate; In benzene; for 0.166667h; Product distribution; presence of triethylamine, (C2H5O)2PONa;
tetrachloromethane
56-23-5

tetrachloromethane

diphosphorous acid tetraethyl ester
21646-99-1

diphosphorous acid tetraethyl ester

diethyl phosphorylchloridite
589-57-1

diethyl phosphorylchloridite

diethyl (trichloromethyl)phosphonate
866-23-9

diethyl (trichloromethyl)phosphonate

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

Conditions
Conditions Yield
tetrachloromethane
56-23-5

tetrachloromethane

triethyl phosphite
122-52-1

triethyl phosphite

diethyl (trichloromethyl)phosphonate
866-23-9

diethyl (trichloromethyl)phosphonate

chloroethane
75-00-3

chloroethane

1,1,1-trichloropropane
7789-89-1

1,1,1-trichloropropane

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

Conditions
Conditions Yield
at 80 ℃; for 4h; Product distribution; Mechanism; Thermodynamic data; ΔG(st.), ΔG(excit.); activation with azobisisobutyronitrile, and inhibition with TCNQ; effect of oxygen.;
90 % Chromat.
80 % Chromat.
at 20 ℃; for 4h; Product distribution; Quantum yield; Mechanism; Irradiation;
90 % Chromat.
80 % Chromat.
chlorothio-trichloro-methane
594-42-3

chlorothio-trichloro-methane

phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

thiophosgene
463-71-8

thiophosgene

thiophosphoric acid <i>O</i>,<i>O</i>'-diethyl ester-<i>S</i>-trichloromethyl ester
1189-83-9

thiophosphoric acid O,O'-diethyl ester-S-trichloromethyl ester

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

Conditions
Conditions Yield
diethoxyoxophosphoranesulfenyl chloride
1186-08-9

diethoxyoxophosphoranesulfenyl chloride

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

diethyl phosphorochloridothioate
2524-04-1

diethyl phosphorochloridothioate

triphenylphosphine sulfide
3878-45-3

triphenylphosphine sulfide

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

Conditions
Conditions Yield
With triphenylphosphine; In dichloromethane; at -50 ℃; for 1.5h; Mechanism; other oxophosphoranesulfenyl chlorides; other tricoordinate phosphorus compounds; regioselectivity;
38.3%
10%
11.7%
40%

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