81445-21-8

Basic information

• Product Name: 2-oxa-6-azabicyclo<3.3.0>octan-3-one
• CAS NO: 81445-21-8
• Molecular Weight: 127.143
• Mol File: 81445-21-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-oxa-6-azabicyclo<3.3.0>octan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxa-6-azabicyclo<3.3.0>octan-3-one(81445-21-8)
• EPA Substance Registry System: 2-oxa-6-azabicyclo<3.3.0>octan-3-one(81445-21-8)

Safety Data

• Hazardous Substances Data: 81445-21-8(Hazardous Substances Data)

Upstream product

• 125172-01-2 Toluene-4-sulfonic acid 2-(5-oxo-2,5-dihydro-furan-2-yl)-ethyl ester 
• 141812-00-2 5-(2-azidoethyl)-2,5-dihydro-2-furanone 
• 95456-65-8 (3aR,6aR)-2-Oxo-hexahydro-furo[3,2-b]pyrrole-4-carboxylic acid benzyl ester 
• 186422-53-7 (4R,5R)-5-allyl-3-benzoyl-4-tert-butoxycarbonylmethyl-2-oxazolidinone 
• 186422-57-1 (4R,5R)-5-allyl-3-tert-butoxycarbonyl-4-tert-butoxycarbonylmethyl-2-oxazolidinone 
• 186422-61-7 (1R,5R)-6-tert-butoxycarbonyl-7-methoxy-2-oxa-6-azabicyclo[3.3.0]octan-3-one 
• 186422-55-9 (4R,5R)-5-allyl-4-tert-butoxycarbonylmethyl-2-oxazolidinone 
• 186422-51-5 (5R)-5-allyl-4-tert-butoxycarbonylmethyl-2-oxazolidinone 
• 186422-59-3 ((2R,3R)-2-Allyl-5-oxo-tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester 
• 171484-99-4 (-)-(1R,5R)-6-tert-butoxycarbonyl-2-oxa-6-azabicyclo[3.3.0]octan-3-one 
• 95456-65-8 (1R,5R)-(-)-6-aza-6-benzyloxycarbonyl-2-oxabicyclo[3.3.0]octan-3-one 

Relevant articles and documents

The Shortest Synthesis of Optically Active Geissman-Waiss Lactone, A Key Synthetic Intermediate for Necine Bases

A short synthesis of (+)-(1R,5R)-2-oxa-6-azabicyclooctan-3-one (the Geissman-Waiss lactone, 1) by palladium (II)-catalyzed intramolecular aminocarbonylation of (R)-N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine (4) available from the Katsuki-Sharple

Cycloaddition Reaction of Cyclic Enecarbamates and Enamides With Ketenes. A Short and Efficient Synthesis of the Geissman-Waiss Lactone.

The synthesis of several 2-aza-bicycloheptan-6-ones has been achieved in a regiospecific manner through a cycloaddition reaction between five-membered cyclic enecarbamates and enamides and free ketenes.The synthetic potential of this new meth