817-95-8Relevant articles and documents
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Roberts et al.
, (1958)
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Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers
Pisella, Guillaume,Gagnebin, Alec,Waser, Jér?me
supporting information, p. 10199 - 10204 (2020/07/17)
Multicomponent reactions provide efficient means to access molecular complexity. Herein, we report a copper-catalyzed three-component reaction of diazo compounds, alcohols and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers. Extensive variations of the three partners of the reaction is possible, leading to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate is postulated as key step for this transformation.
Silica-supported HClO4 promotes catalytic solvent- and metal-free O-H insertion reactions with diazo compounds
Gallo, Rafael Douglas C.,Burtoloso, Antonio C. B.
, p. 4547 - 4556 (2018/10/17)
Solvent-free O-H insertion reactions in the presence of diazo carbonyl compounds were carried-out in very mild conditions. Unlike the traditional metal-catalysed version, employing rhodium acetate dimer, this method uses eco-friendly silica-supported HClO4 as the catalyst. Only 0.3 mol% of this Br?nsted acid catalyst, that can also be recycled several times, is necessary to guarantee very good yields (up to 97%) in the O-H insertion reactions. Reaction set-up is simple and permitted the preparation of forty-three α-hydroxy and α-alkoxy esters/ketones in just 1 h and at room temperature.
Acetal carbonylation product preparation method
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Paragraph 0088; 0089, (2017/02/24)
The present invention provides a method for producing an ethylene glycol production intermediate acetal carbonylation product through an acetal carbonylation reaction, wherein the method comprises that a raw material acetal and raw material gas carbon monoxide are subjected to a carbonylation reaction with a catalyst supporting an acidic EMT and FAU eutectic structure molecular sieve through a reactor to obtain the product acetal carbonylation product. According to the present invention, the conversion rate of the raw material acetal is high, the selectivity of the acetal carbonylation product is high, the service life of the catalyst is long, the additional solvent is not required, the reaction conditions are mild, the continuous production can be achieved, the industrial application potential is provided, and ethylene glycol can be produced from the obtained acetal carbonylation product sequentially through hydrogenation and hydrolysis.