81786-51-8

Basic information

• Product Name: Benzenebutanol, 4-methoxy-, methanesulfonate
• CAS NO: 81786-51-8
• Molecular Formula: C12H18O4S
• Molecular Weight: 258.339
• Mol File: 81786-51-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzenebutanol, 4-methoxy-, methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanol, 4-methoxy-, methanesulfonate(81786-51-8)
• EPA Substance Registry System: Benzenebutanol, 4-methoxy-, methanesulfonate(81786-51-8)

Safety Data

• Hazardous Substances Data: 81786-51-8(Hazardous Substances Data)

Upstream product

• 52244-70-9 4-(4-methoxyphenyl)butan-1-ol 
• 124-63-0 methanesulfonyl chloride 
• 80174-16-9 1-(4’-methoxyphenyl)butan-1,4-diol 
• 24165-60-4 1-(4-methoxyphenyl)but-3-en-1-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 52999-15-2 4-(p-methoxyphenyl)-3-butyn-1-ol 
• 100-66-3 methoxybenzene 
• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 

Downstream Products

• 149506-42-3 5-(4-methoxyphenyl)pentanenitrile 
• 7508-04-5 5-(4-methoxyphenyl)pentanoic acid 
• 955360-38-0 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-37-9 4-[(4-chlorophenyl)methyl]-2-[((2S)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-35-7 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955360-34-6 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone 
• 955359-72-5 GSK-1004723 

Relevant articles and documents

Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2

Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.

Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis

A general and efficient method for heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis to access a wide range of structurally diverse oxygen as well as nitrogen heterocycles up to a gram scale is reported. The potential application of this new methodology is demonstrated by the total synthesis of (-)-codonopsinine and (+)-centrolobine. Herein it is proposed that selectfluor, unlike a fluorinating reagent, acts as an oxidative quencher and a hydrogen radical acceptor.

The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis

A series of potent phthalazinone-based human H1 and H 3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogues (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, respectively, vs 9.7 for the clinical gold-standard azelastine, and H3 potency (pK i 9.6 and 9.5, respectively, vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clinical dose, should limit the potential of engaging CNS-related side-effects associated with H 1 or H3 antagonism.