81945-73-5

Basic information

• Product Name: 1-hydroxy-1H-pyrazole
• Synonyms: 1-hydroxy-1H-pyrazole;1H-Pyrazol-1-ol;1H-Pyrazole, 1-hydroxy-;Einecs 279-854-3;1-hydroxy-1,2-diazole;1-Hydroxypyrazole;N-Hydroxypyrazole;Pyrazol-1-ol
• CAS NO: 81945-73-5
• Molecular Formula: C₃H₄N₂O
• Molecular Weight: 84.07666
• EINECS: 279-854-3
• Mol File: 81945-73-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 74℃
• Boiling Point: 242.3°Cat760mmHg
• Flash Point: 100.3°C
• Appearance: /
• Density: 1.3g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.38±0.58(Predicted)
• CAS DataBase Reference: 1-hydroxy-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-1H-pyrazole(81945-73-5)
• EPA Substance Registry System: 1-hydroxy-1H-pyrazole(81945-73-5)

Safety Data

• Hazardous Substances Data: 81945-73-5(Hazardous Substances Data)

Usage

Uses

1H-Pyrazol-1-ol, is an intermediate in the synthesis of various pharmaceutical compounds containing pyrazole. It can be used for the construction of multidentate ligands.

Upstream product

• 71989-66-7 4-bromo-3,5-dimethyl-1-hydroxypyrazole 2-oxide 
• 288-13-1 NH-pyrazole 
• 100159-47-5 1-(benzyloxy)pyrazole 
• 145162-47-6 1-benzyl-1H-pyrazole-2-oxide 
• 1383843-59-1 3,4,5-trinitro-1H-pyrazol-1-ol 

Downstream Products

• 145162-47-6 1-benzyl-1H-pyrazole-2-oxide 
• 145162-48-7 2-(p-methoxybenzyl)pyrazole 1-oxide 
• 548767-67-5 4-Phenyl-piperazine-1-carboxylic acid pyrazol-1-yl ester 
• 548767-62-0 Morpholine-4-carboxylic acid pyrazol-1-yl ester 
• 142346-90-5 N-2-[4-(1,1-dimethylethoxy)phenoxy]ethoxypyrazole 
• 445411-86-9 2-(pyrazol-1-yloxy)benzonitrile 
• 100159-47-5 1-(benzyloxy)pyrazole 
• 548765-36-2 methyl-phenyl-carbamic acid pyrazol-1-yl ester 
• 784190-13-2 5-bromo-1-(2,6-difluorobenzyl)-1H-pyrazole 

Relevant articles and documents

Synthesis and properties of 3,4,5-trinitropyrazole-1-ol and its energetic salts

3,4,5-Trinitropyrazole-1-ol and its nitrogen-rich salts were synthesized and well characterized by 1H, 13C NMR (some with 15N NMR), and IR spectroscopy, and by elemental analysis. Additionally, the structures of the ammoni

SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE OF SENSITIVE LIPASE

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Preparation of 1-hydroxypyrazoles and 1-hydroxy-1,2,3-triazoles by dealkylation of pyrazole and triazole N-oxides

1-Hydroxypyrazoles were obtained from 2-benzylpyrazole 1-oxides by debenzylation with iodotrimethylsilane. 1-Hydroxy-1,2,3-triazoles were achieved from 2-benzyltriazole 1-oxides by debenzylation effected with conc. hydrobromic acid or from 2- or 3-p-methoxybenzyltriazole 1-oxides by de-p methoxybenzylation accomplished by treatment with conc. sulfuric acid. 1-Methoxy-1,2,3-triazole was obtained by de-p-methoxybenzylation of 1-methoxy-3-p-methoxybenzyl-1,2,3-triazolium tetrafluoroborate accomplished by treatment with conc. sulfuric acid. 1-Hydroxypyrazole was selectively N-benzylated in absence of base to give 2-benzylpyrazole 1-oxide which, upon selective substitution at the 3-position and subsequent debenzylation, produced 3-substituted 1-hydroxypyrazole. Acta Chemika Scandinavica 1996.