82010-31-9

Basic information

• Product Name: BOC-L-LEUCINOL
• Synonyms: BOC-(S)-2-AMINO-4-METHYL-1-PENTANOL;BOC-LEUCINOL;BOC-LEU-OL;BOC-L-LEUCINOL;BOC-L-LEU-OL;(S)-2-(TERT-BUTYLOXYCARBONYL-AMINO)-4-METHYL-1-PENTANOL;(S)-(-)-2-(BOC-AMINO)-4-METHYL-1-PENTANOL;N-T-BOC-L-LEUCINOL
• CAS NO: 82010-31-9
• Molecular Formula: C₁₁H₂₃NO₃
• Molecular Weight: 217.31
• Product Categories: Amino Acids;Leucine [Leu, L];Amino Alcohols;Boc-Amino acid series;Amino Acid Derivatives;Amino Alcohols;Peptide Synthesis
• Mol File: 82010-31-9.mol
• Article Data: 93

Chemical Properties

• Boiling Point: 213 °C
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Viscous Liquid
• Density: 0.983
• Vapor Pressure: 2.8E-05mmHg at 25°C
• Refractive Index: n20/D 1.450
• Storage Temp.: -15°C
• PKA: 12.11±0.46(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 4178460
• CAS DataBase Reference: BOC-L-LEUCINOL(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-LEUCINOL(82010-31-9)
• EPA Substance Registry System: BOC-L-LEUCINOL(82010-31-9)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 82010-31-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H23NO3/c1-8(2)6-9(7-13)12-10(14)15-11(3,4)5/h8-9,13H,6-7H2,1-5H3,(H,12,14)/t9-/m0/s1

Upstream product

• 172096-97-8 (4S)-N-(tert-butyloxycarbonyl)-4-isobutyl-1,3-oxazolidin-5-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 58910-80-8 L-leucinol oxalate 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 543-27-1 isobutyl chloroformate 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 1234196-13-4 2-(tert-butoxycarbonylamino)-4-methylpentyl acetate 
• 34619-03-9 tert-butyldicarbonate 
• 61-90-5 L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 25462-20-8 2-hydroxymethyl-4-methylpentan-1-ol 
• 39520-24-6 Isobutylmalonsaeure-dimethylester 

Downstream Products

• 578764-69-9 (S)-[1-(4-bromophenoxymethyl)-3-methylbutyl]carbamic acid tert-butyl ester 
• 781650-77-9 tert-butyl [(1S)-(2,4-dibromophenoxymethyl)-3-methylbutyl]carbamate 
• 578764-70-2 (S)-1-(4-bromophenoxymethyl)-3-methylbutylamine 
• 578764-63-3 (S,S)-N,N'-bis[1-(4-bromophenoxymethyl)-3-methylbutyl]perylene-3,4:9,10-tetracarboxylicbisimide 
• 1214750-43-2 tert-butyloxycarbonyl-L-leucinol benzyl ether 
• 854402-91-8 (3S)-3-Amino-2-hydroxy-5-methyl-N-(2-phenoxyethyl)hexanamide hydrochloride 
• 3392-09-4 Boc-Leu-ONSu 
• 133407-82-6 N-(benzyloxycarbonyl)-leucinylleucinylleucinal 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 1595280-82-2 (S,E)-tert-butyl (8-(benzylamino)-2-methyl-8-oxooct-5-en-4-yl)carbamate 
• 1595280-81-1 (S,E)-tert-butyl (8-diazo-2-methyl-7-oxooct-5-en-4-yl) carbamate 

Relevant articles and documents

COMPOUNDS AND METHODS OF USE

Disclosed are heterocyclic compounds or their pharmaceutically acceptable salts with ferroptosis-inducing activity, Those compounds or their pharmaceutically acceptable salts can be used to treat cancer.

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature. The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently undergoes the N-tert-butyloxycarbonylation under the developed protocol. The aminoalcohol, aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign.

Structure Determination, Biosynthetic Origin, and Total Synthesis of Akazaoxime, an Enteromycin-Class Metabolite from a Marine-Derived Actinomycete of the Genus Micromonospora

A new enteromycin-class antibiotic, akazaoxime (1), possessing an aldoxime functionality in place of O-methyl nitronic acid, was isolated from the cultured extract of a marine-derived actinomycete of the genus Micromonospora, along with known A-76356 (2). The structure of 1, including the absolute stereochemistry of three chiral centers, was established by comprehensive analysis of nuclear magnetic resonance (NMR) and mass spectrometry data coupled with magnetic anisotropy analysis of its phenylglycine methyl ester derivatives. The stereochemistry of 2, not determined previously, was proven to be the same as that of 1 on the basis of the similarity of their NMR and specific rotation data. Precursor feeding experiments using 13C-labeled compounds elucidated that the carbon skeletons of 1 and 2 are constructed from propionate (methylmalonate), leucine, and glycine. Establishment of the concise and flexible synthetic route to 1 enabled us to implement biological evaluation of 1 and its unnatural analogues, demonstrating weak to moderate antimicrobial activities of 1 against Gram-positive Kocuria rhizophila [minimum inhibitory concentration (MIC) of 50 μg/mL] and those of synthetic analogues against a plant pathogen Glomerella cingulata (MIC of 50 μg/mL) and a human pathogen Trichophyton rubrum (MIC of 25-50 μg/mL).