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824430-78-6

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  • (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine,(2R,3R)-2,3-dihydroxybutanedioic acid

    Cas No: 824430-78-6

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  • 1H-3-Benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, (1R)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1)

    Cas No: 824430-78-6

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824430-78-6 Usage

General Description

"(R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine (2R,3R)-2,3-dihydroxysuccinate" is a chemical compound that consists of a tetrahydrobenzo[d]azepine core with a chloro substitution at the 8 position and a methyl group at the 1 position. It also contains a (2R,3R)-2,3-dihydroxysuccinate moiety. (R)-8-Chloro-1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine (2R,3R)-2,3-dihydroxysuccinate has potential pharmaceutical applications due to its structural features and functional groups. It may possess biological activity that could be of interest for therapeutic purposes, and further research and development may be warranted to explore its potential use in medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 824430-78-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,4,4,3 and 0 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 824430-78:
(8*8)+(7*2)+(6*4)+(5*4)+(4*3)+(3*0)+(2*7)+(1*8)=156
156 % 10 = 6
So 824430-78-6 is a valid CAS Registry Number.

824430-78-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine,(2R,3R)-2,3-dihydroxybutanedioic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:824430-78-6 SDS

824430-78-6Relevant articles and documents

Method for preparing lorcaserin

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Paragraph 0035-0036; 0041, (2020/08/22)

The invention discloses a method for preparing lorcaserin. Specifically, the method comprises the steps: taking p-chlorophenylacetonitrile as an initial raw material, preparing p-chlorophenylethylamine through reduction; carrying out a reaction with p-toluenesulfonyl chloride to form an amino occupying intermediate; enabling the intermediate to carry out a reaction with monochloroacetone under analkaline condition to form N-(2-(4-chlorphenyl)ethyl)-4-methyl-N-(2-propionyl)benzenesulfonamide, and then carrying out reduction, chlorination, p-toluenesulfonyl removal and intramolecular Friedel-Crafts alkylation to synthesize 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzoazepine, carrying out L-(+)-tartaric acid resolution and alkalization on azepine to remove tartaric acid, and acting with hydrogen chloride diethyl ether to salify to prepare lorcaserin. The method has the characteristics of simple synthesis method, good reaction selectivity, high product purity, environmental protectionand low preparation cost.

Preparation method of lorcaserin intermediate

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Paragraph 0027, (2017/08/29)

The invention discloses a preparation method of a lorcaserin intermediate (I). According to the preparation method, p-chlorobenzyl cyanide is taken as the primary raw material, and the lorcaserin intermediate (I) is obtained after reduction reactions and condensation reactions. The primary raw materials (p-chlorobenzyl cyanide and 1-chloro-2-propanol) are cheap and easily available; raw materials, which can easily get polluted and are explosive, such as sulfoxide chloride, hydrobromic acid, borane, and the like are not used; the preparation method will not produce a large amount of wastewater and is beneficial for the environment protection; moreover, the requirements on the protection of workers are lowered, and safe production is guaranteed. The route design is novel, the raw materials are easily available, the operation is simple and feasible, and the preparation method is environment-friendly and can be applied to massive industrial production.

PROCESSES FOR THE PREPARATION OF LORCASERIN

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Paragraph 0093; 0094, (2016/10/20)

The present invention relates to stable crystalline Form A of lorcaserin hydrochloride of Formula (IA) and processes for its preparation. The invention also relates to processes for the preparation of lorcaserin and pharmaceutically acceptable salts, solvates and hydrates thereof.

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