82645-11-2

Basic information

• Product Name: 4-(TRIMETHYLSILYL)-1H-INDOLE 98
• Synonyms: 4-(TRIMETHYLSILYL)-1H-INDOLE 98;4-(Trimethylsilyl)-1H-indole 98%;1H-Indole,4-(trimethylsilyl)-;1H-Indol-4-Yl(Trimethyl)Silane
• CAS NO: 82645-11-2
• Molecular Formula: C11H15NSi
• Molecular Weight: 189.3325
• Product Categories: blocks;IndolesOxindoles;Indole
• Mol File: 82645-11-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 58-60
• Boiling Point: 298.2 °C at 760 mmHg
• Flash Point: 134.2 °C
• Appearance: /
• Density: 1 g/cm³
• Vapor Pressure: 0.00228mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-(TRIMETHYLSILYL)-1H-INDOLE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIMETHYLSILYL)-1H-INDOLE 98(82645-11-2)
• EPA Substance Registry System: 4-(TRIMETHYLSILYL)-1H-INDOLE 98(82645-11-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 82645-11-2(Hazardous Substances Data)

Usage

General Description

4-(Trimethylsilyl)-1H-indole 98 is a chemical compound that belongs to the class of indole derivatives. It is a trimethylsilyl-substituted form of 1H-indole, which is commonly used in organic chemistry as a versatile building block for the synthesis of pharmaceuticals, agrochemicals, and other biologically active compounds. The trimethylsilyl group, consisting of three methyl groups attached to a silicon atom, provides stability and protection to the indole ring during various chemical reactions. 4-(TRIMETHYLSILYL)-1H-INDOLE 98 is highly pure with a 98% assay, making it suitable for use in research and manufacturing applications. It is important to handle this chemical with caution and follow proper safety protocols due to its potential hazards and toxicity.

InChI:InChI=1/C11H15NSi/c1-13(2,3)11-6-4-5-10-9(11)7-8-12-10/h4-8,12H,1-3H3

Upstream product

• 52488-36-5 4-bromo-1H-indole 
• 75-77-4 chloro-trimethyl-silane 
• 120-72-9 indole 
• 17983-42-5 trimethylsilyl indole 
• 83188-11-8 1,4-bis(trimethylsilyl)indole 
• 123191-00-4 1-(triisopropylsilyl)-1H-indole 

Downstream Products

• 92013-04-2 1-Acetyl-6-chloroacetylindole 

Relevant articles and documents

The Direct C-4 Substitution of Indole; An X-Ray Crystal Structure Analysis of 4-(Trimethylsilyl)indole

Indole was converted into the 1,4-diacetyl and 1-acetyl-4-(3-chloropropanoyl) derivatives by direct C-4 electrophilic substitution via 4-(trimethylsilyl)indole (3c); the structure of (3c) was confirmed by a single crystal X-ray analysis.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to antiviral agents. Specifically, the present invention relates to compounds of formula I which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.