83184-43-4Relevant articles and documents
Ionization, tautomerism and molecular conformation in aqueous solution of the histamine H2-receptor antagonist mifentidine
Bazzano,Vavoni,Mondoni,et al.
, p. 27 - 33 (2007/10/02)
Ionization (pK(a)) and tautomeric (K(t)) constants of mifentidine (DA4577) have been determined in aqueous solution. The predominant molecular species at physiological pH (7.4) is the monocationic form (95.3%) at the formamidine moiety, with the imidazole
(Imidazolylphenyl)formamidines. A structurally novel class of potent histamine H2 receptor antagonists
Donetti,Cereda,Bellora,Gallazzi,Bazzano,Vanoni,Del Soldato,Micheletti,Pagani,Giachetti
, p. 380 - 386 (2007/10/02)
Structure-activity considerations of N(α)-guanylhistamine, the first compound found with detectable H2-antagonist activity, led to the synthesis of a series of conformationally rigid guanylhistamine analogues, namely (imidazolylphenyl)guanidine