83207-58-3 Usage
Uses
Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.
Definition
ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from
benefits
Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.
Health effects
As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.
Pharmaceutical Applications
Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 83207-58-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,2,0 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 83207-58:
(7*8)+(6*3)+(5*2)+(4*0)+(3*7)+(2*5)+(1*8)=123
123 % 10 = 3
So 83207-58-3 is a valid CAS Registry Number.
InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
83207-58-3Relevant articles and documents
TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XV. CYCLOSIVERSIOSIDES B AND D FROM Astragalus basineri
Umarova, R. U.,Svechnikova, A. N.,Abdullaev, N. D.,Gorovich, M. B.,Abubakirov, N. K.
, p. 174 - 177 (1984)
Two new glycosides have been isolated from the roots of the plant Astragalus basineri Trautv. - cyclosiversiosides B and D.It has been shown that cyclosiversioside B is cyclosiversigenin 3-O-(2',3'-di-O-acetyl-β-D-xylopyranoside)-6-O-β-D-glucopyranoside.Cyclosiversioside D is cyclosiversigenin 3-O-(2'-O-acetyl-β-D'-xylopyranoside)-6-O-β-D-glucopyranoside.
Synthetic Access Toward Cycloastragenol Glycosides
Liu, Ting,Liao, Jin-Xi,Hu, Yang,Tu, Yuan-Hong,Sun, Jian-Song
, p. 4170 - 4178 (2017/04/27)
The first efficient synthetic approach toward four types of the cycloartane glycosides, the cycloastragenol 25-O; 3-O; 3,6-O-bis; and 3,25-O-bisglycoside, have been established, which featured the PPY-mediated, concentration-controlled acetylation and Au(I)-catalyzed Yu glycosylation. Through the synthetic investigation, the reactivity sequence of the four OHs in cycloastragenol was fixed for the first time and a detour strategy for the highly efficient removal of bulky pivaloyl protecting groups was discovered.
Saponin and Sapogenol. XXXV. Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (2). Astragalosides I, II, and IV, acetylastragaloside I and isoastragalosides I and II
Kitagawa,Wang,Saito,et al.
, p. 698 - 708 (2007/10/02)
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