832112-48-8Relevant articles and documents
1-isobutyric acyl-3-phenyl -1,4-dihydro -1, 2, 4, 5-tetrazine, and its preparation and use
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Paragraph 0024-0027, (2017/02/24)
The invention discloses 1-isobutyryl-3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine and preparation and application thereof, wherein the structure of the 1-isobutyryl-3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine is as shown in formula (I). The preparation method of the 1-isobutyryl-3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine is as follows: adding 3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine as shown in formula (II) into an organic solvent A, then adding an alkaline catalyst, dropwise adding isobutyric anhydride or isobutyryl chloride at 0 to 12 DEG C, after addition of the isobutyric anhydride or isobutyryl chloride is completed, reacting at room temperature, after the reaction is completed, separating and purifying the reaction liquid to obtain the 1-isobutyryl-3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine as shown in the formula (I). The alkaline catalyst is one of the following substances: triethylamine, N, N-dimethyl aniline, sodium hydroxide or potassium hydroxide. The invention also provides the application of the 1-isobutyryl-3-phenyl-1, 4-dihydro-1,2,4,5-tetrazine in preparation of drugs for prevention or treatment of human breast cancer or lung cancer.
Synthesis of 3-Phenyl-5-silylpyridazines by Regioselective -Cycloadditions
Birkofer, Leonhard,Haensel, Edward,Steigel, Alois
, p. 2574 - 2585 (2007/10/02)
The cycloaddition of 3-phenyl-1,2,4,5-tetrazine (1) with the silylethyne 2a proceeds highly regioselectively to give 3-phenyl-5-(trimethylsilyl)pyridazine (3a).Similarly the reactions of 1 with the silylalkynes 2b - f, the silylalkynones 2g - i, and the s
