83430-90-4Relevant articles and documents
CYCLODIENONES. 9. REACTION 4-HALO-2,4,6-TRI-TERT-BUTYL-2,5-CYCLOHEXADIEN-1-ONES WITH PYRAZOLES AND PREPARATION OF 1-(2-HYDROXYPHENYL)- AND 1-(4-HYDROXYPHENYL)PYRAZOLES
Fukata, Guouki,Itoh, Takashi,Tashiro, Masashi
, p. 1487 - 1495 (2007/10/02)
Reaction of 4-halo-2,4,6-tri-tert-butyl-2,5-cyclohexadien-1-one (1) with pyrazoles (8) afforded 4-(pyrazol-1-yl)-2,4,6-tri-tert-butyl-2,5-cyclohexadien-1-ones (9), 1-(4-hydroxy-3,5-di-tert-butylphenyl)- and 1-(2-hydroxy-3,5-di-tert-butylphenyl)pyrazoles (10 and 11) together with by-products.De-tert-butylation of 9, 10 and 11 was carried out in boiling 85percent H3PO4 to give the corresponding 1-(4-hydroxyphenyl)- and 1-(2-hydroxyphenyl)pyrazoles (17 and 18) in good yields, respectively.