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FMOC-HIS(BZL)-OH, also known as 9-fluorenylmethoxycarbonyl-L-histidine(benzyl), is an amino acid derivative that plays a crucial role in chemical synthesis and peptide chemistry. It is characterized by the presence of a fluorenylmethoxycarbonyl (Fmoc) protecting group, which is commonly used in solid-phase peptide synthesis to protect the amino group of histidine. The benzyl group attached to the imidazole ring of histidine provides additional steric hindrance and stability to the molecule.

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  • 3-(1-benzylimidazol-4-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

    Cas No: 84030-19-3

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  • 3-(1-benzylimidazol-4-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

    Cas No: 84030-19-3

  • USD $ 1.0-1.0 / Metric Ton

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  • 84030-19-3 Structure
  • Basic information

    1. Product Name: FMOC-HIS(BZL)-OH
    2. Synonyms: FMOC-N-IM-BENZYL-L-HISTIDINE;FMOC-HIS(BZL)-OH;FMOC-HISTIDINE(BZL)-OH;N-ALPHA-FMOC-N(IM)-BENZYL-L-HISTIDINE;N-ALPHA-FMOC-IM-BENZYL-L-HISTIDINE;na-fmoc-im-benzyl-L-histidine;1-benzyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidine;nα-fmoc-n(im)-benzyl-l-histidine
    3. CAS NO:84030-19-3
    4. Molecular Formula: C28H25N3O4
    5. Molecular Weight: 467.52
    6. EINECS: 281-790-6
    7. Product Categories: N/A
    8. Mol File: 84030-19-3.mol
  • Chemical Properties

    1. Melting Point: 167-171℃
    2. Boiling Point: 739.4°C at 760 mmHg
    3. Flash Point: 401°C
    4. Appearance: /
    5. Density: 1.3g/cm3
    6. Vapor Pressure: 5.88E-23mmHg at 25°C
    7. Refractive Index: 1.662
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 3.07±0.10(Predicted)
    11. CAS DataBase Reference: FMOC-HIS(BZL)-OH(CAS DataBase Reference)
    12. NIST Chemistry Reference: FMOC-HIS(BZL)-OH(84030-19-3)
    13. EPA Substance Registry System: FMOC-HIS(BZL)-OH(84030-19-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS:
    6. F: 21
    7. HazardClass: N/A
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 84030-19-3(Hazardous Substances Data)

84030-19-3 Usage

Uses

Used in Chemical Synthesis:
FMOC-HIS(BZL)-OH is used as a building block in chemical synthesis for the preparation of various organic compounds and pharmaceuticals. Its unique structure allows for selective reactions and modifications, making it a versatile component in the synthesis of complex molecules.
Used in Peptide Chemistry:
In peptide chemistry, FMOC-HIS(BZL)-OH is used as a protected amino acid for the synthesis of peptides and proteins. The Fmoc protecting group can be selectively removed under mild conditions, allowing for the stepwise assembly of peptide chains. This protects the amino group of histidine from unwanted side reactions during the synthesis process.
Used in Drug Discovery and Development:
FMOC-HIS(BZL)-OH is employed in drug discovery and development as a key component in the synthesis of bioactive peptides and peptidomimetics. Its incorporation into peptide sequences can modulate the biological activity, stability, and pharmacokinetic properties of the resulting compounds, leading to the development of novel therapeutic agents.
Used in Research and Diagnostics:
FMOC-HIS(BZL)-OH is also used in research and diagnostic applications, such as the synthesis of probes and markers for biological assays, as well as the development of new analytical methods for the detection and quantification of biomolecules.

Check Digit Verification of cas no

The CAS Registry Mumber 84030-19-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,0,3 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 84030-19:
(7*8)+(6*4)+(5*0)+(4*3)+(3*0)+(2*1)+(1*9)=103
103 % 10 = 3
So 84030-19-3 is a valid CAS Registry Number.
InChI:InChI=1/C28H25N3O4/c32-27(33)26(14-20-16-31(18-29-20)15-19-8-2-1-3-9-19)30-28(34)35-17-25-23-12-6-4-10-21(23)22-11-5-7-13-24(22)25/h1-13,16,18,25-26H,14-15,17H2,(H,30,34)(H,32,33)

84030-19-3 Well-known Company Product Price

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  • Aldrich

  • (47591)  Fmoc-His(Bzl)-OH  ≥98.0% (HPLC)

  • 84030-19-3

  • 47591-5G-F

  • 1,715.22CNY

  • Detail

84030-19-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(1-benzylimidazol-4-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid

1.2 Other means of identification

Product number -
Other names EINECS 281-790-6

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84030-19-3 SDS

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