84358-13-4

Basic information

• Product Name: N-BOC-piperidine-4-carboxylic acid
• Synonyms: AURORA KA-3052;BOC-PIC(4)-OH;BOC-PIPERIDINE-4-CARBOXYLIC ACID;BOC-L-ISONIPECOTIC ACID;BOC-ISONICOT(HEXAHYDRO)-OH;BOC-ISONIPECOTIC ACID;BOC-INP;BOC-INP-OH
• CAS NO: 84358-13-4
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.27
• EINECS: 1312995-182-4
• Product Categories: Heterocycles;pharmacetical;PiperidineDerivative;Piperidine;Amino Acids;Piperidines;Piperidine Series
• Mol File: 84358-13-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 148-153 °C
• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: White/Crystalline Powder
• Density: 1.164 g/cm³
• Vapor Pressure: 6.15E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 4.56±0.20(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 5533442
• CAS DataBase Reference: N-BOC-piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-piperidine-4-carboxylic acid(84358-13-4)
• EPA Substance Registry System: N-BOC-piperidine-4-carboxylic acid(84358-13-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 84358-13-4(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Uses

It is a pharmaceutical intermediate. he camptothecin ester of isonipecotic acid is installed on a triazine dendrimer intermediate obtained through an iterative, scalable route to ultimately yield cationic and PEGylated targets with activities in cell culture comparable to free drug.

InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-8(5-7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/p-1

Upstream product

• 1146955-04-5 4-bromo-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 307496-27-1 2-bromobenzylzinc(II) bromide 

Downstream Products

• 195503-42-5 4-(Methyl-phenyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 327048-63-5 N-(tert-butoxycarbonyl)-4-(4-fluorophenylmethylamidoacetyl)piperidine 
• 177990-33-9 4-Benzyloxycarbonyl-1-tert-butoxycarbonylpiperidine 
• 293744-26-0 tert-butyl 4-{[(2-bromophenyl)amino]carbonyl}piperidine-1-carboxylate 
• 514221-85-3 piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decylsulfanyl)-phenyl] ester 
• 736150-27-9 4-[3-(4-phenoxyphenyl)-3-oxopropanoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 736150-25-7 4-[3-(4-methoxyphenyl)-3-oxopropanoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 419571-68-9 4-(3-oxo-butyrl)-piperidine-1-carboxylic acid tert-butyl ester 
• 905858-50-6 4-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 905858-53-9 (S)-2-[((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 162881-76-7 tert-butyl 4[(phenylamino)carbonyl]piperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 

Relevant articles and documents

Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)-C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp3)-over C(sp2)-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species. This journal is