846023-24-3

Basic information

• Product Name: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE
• Synonyms: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE;AcetaMide,2-cyano-N-(2,4-dichloro-5-Methoxyphenyl)-
• CAS NO: 846023-24-3
• Molecular Formula: C₁₀H₈Cl₂N₂O₂
• Molecular Weight: 259.09
• Mol File: 846023-24-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 180-181 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 462.4 °C at 760 mmHg
• Flash Point: 233.4 °C
• Appearance: /
• Density: 1.436 g/cm³
• Vapor Pressure: 9.92E-09mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.71±0.10(Predicted)
• CAS DataBase Reference: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(846023-24-3)
• EPA Substance Registry System: 2-CYANO-N-(2,4-DICHLORO-5-METHOXYPHENYL) ACETAMIDE(846023-24-3)

Safety Data

• Hazardous Substances Data: 846023-24-3(Hazardous Substances Data)

Usage

Uses

2-cyano-N-(2,4-dichloro-5-methoxyphenyl)acetamide (cas# 846023-24-3) is a useful research chemical.

Chemical Properties

Pale yellow powder

InChI:InChI=1/C10H8Cl2N2O2/c1-16-9-5-8(6(11)4-7(9)12)14-10(15)2-3-13/h4-5H,2H2,1H3,(H,14,15)

Upstream product

• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 372-09-8 cyanoacetic acid 
• 538-75-0 dicyclohexyl-carbodiimide 
• 67669-19-6 N-(2,4-dichloro-5-hydroxyphenyl)acetamide 
• 591-27-5 m-Hydroxyaniline 

Downstream Products

• 380843-75-4 bosutinib 
• 1334310-24-5 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-28-9 C₃₁H₃₃Cl₂N₇O₂ 
• 1334311-15-7 C₃₀H₃₁Cl₂N₇O₂ 
• 1334311-68-0 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-23-4 C₂₉H₃₁Cl₂N₇O₂ 
• 1334396-27-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-46-4 C₂₇H₂₈Cl₂N₈O₂ 
• 1334310-95-0 C₂₆H₂₅Cl₂N₇O₂ 
• 1334310-22-3 C₂₉H₂₉Cl₂N₇O₂ 
• 1334312-08-1 C₂₈H₂₇Cl₂N₇O₂ 
• 1334310-77-8 C₂₈H₂₉Cl₂N₇O₂ 
• 1334309-74-8 C₂₇H₂₇Cl₂N₇O₂ 
• 1334396-29-0 C₂₀H₁₃Cl₂N₃O₂ 

Relevant articles and documents

A PROCESS FOR THE PREPARATION OF BOSUTINIB

The present invention provides an improved process for the preparation of bosutinib and its intermediate 2-cyano-N-(2, 4-dichloro-5-methoxyphenyl)acetamide.

Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles

Compound 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5- methoxyphenyl)amino]-3-quinolinecarbonitrile, is a potent inhibitor of Src kinase activity. We previously reported that analogs of 1 with thiophene groups at C-7 retained the Src activity of

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.