849-01-4Relevant articles and documents
HFIP-Catalyzed Difluoroalkylation of Propargylic Alcohols to Access Tetrasubstituted Difluoroalkyl Allenes
Li, Jinshan,Xi, Wenxue,Liu, Saimei,Ruan, Chenxi,Zheng, Xiaochun,Yang, Jianguo,Wang, Lei,Wang, Zhiming
, p. 7264 - 7269 (2021)
A hexafluoroisopropanol (HFIP)-catalyzed difluoroalkylation of propargylic alcohols with difluoroenoxysilanes to access structurally diverse tetrasubstituted difluoroalkyl allenes has been developed. This convenient procedure enables the rapid construction of highly functionalized multisubstituted fluorinated allenes in a mild and straightforward way. Furthermore, the synthetic potential of this methodology has been demonstrated by the facile synthesis of various structurally interesting fluorine-containing molecules such as gem-difluorosubstituted dihydropyran, tetrasubstituted CF2H-allene, and multisubstituted fluorinated cyclopentanone derivatives.
Ruthenium-catalyzed propargylic substitution reaction of propargylic alcohols with thiols: A general synthetic route to propargylic sulfides
Inada, Youichi,Nishibayashi, Yoshiaki,Hidai, Masanobu,Uemura, Sakae
, p. 15172 - 15173 (2002)
A novel cationic methanethiolate-bridged diruthenium complex [Cp*RuCl(μ2-SMe)2RuCp*(OH2)]OTf (1e) has been disclosed to promote the catalytic propargylic substitution reaction of propargylic alcohols bearing not only termi
Photoredox Catalyzed Radical Cascade Aroylation (Sulfonylation)/Cyclization Enables Access to Fused Indolo-pyridones
Yang, De-Yong,Liu, Liang,Gu, Jia-Yi,He, Yan-Hong,Guan, Zhi
, p. 18042 - 18055 (2021/12/17)
A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused Indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to N-alkyl-acryloyl-1H-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.
Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions
Joseph, Devaneyan,Lee, Sunwoo,Park, Myeong Seong
supporting information, p. 6227 - 6232 (2021/07/28)
N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.
