850040-08-3Relevant articles and documents
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR?3t Allosteric Inhibitors for Autoimmune Diseases
Anthony, Neville,Azevedo, Rita,Barr, Kenneth,Cals, Jos,Correll, Craig C.,Daniels, Matthew,Deshmukh, Sujal,Ferguson, Heidi,Hegde, Laxminarayan G.,Karstens, Willem Jan,Lapointe, Blair T.,MacLean, John,Moy, Lily Y.,Nagpal, Sunil,Oubrie, Arthur,Palte, Rachel L.,Parthasarathy, Gopal,Richard Miller, J.,Sciammetta, Nunzio,Simov, Vladimir,Van Der Stelt, Mario,Van Eenenaam, Hans,Wesley Trotter, B.,Woodhouse, Janice D.,Zhang, Hongjun
supporting information, (2020/02/06)
The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and affects the prod
3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
-
Page/Page column 53, (2014/03/22)
The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
Novel amides useful for treating pain
-
Page/Page column 19-20, (2010/02/11)
The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R6, R7 and R8 are defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.