850363-55-2

Basic information

• Product Name: 1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-diMethylethyl) 3-Methyl ester
• Synonyms: 1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-diMethylethyl) 3-Methyl ester;1-tert-Butyl 3-methyl 5-iodo-1H-indazole-1,3-dicarboxylate
• CAS NO: 850363-55-2
• Molecular Formula: C14H15IN2O4
• Molecular Weight: 402.18437
• Mol File: 850363-55-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-diMethylethyl) 3-Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-diMethylethyl) 3-Methyl ester(850363-55-2)
• EPA Substance Registry System: 1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-diMethylethyl) 3-Methyl ester(850363-55-2)

Safety Data

• Hazardous Substances Data: 850363-55-2(Hazardous Substances Data)

Usage

General Description

The chemical "1H-Indazole-1,3-dicarboxylic acid, 5-iodo-, 1-(1,1-dimethylethyl) 3-methyl ester" is a compound with potential pharmaceutical applications. It is a derivative of 1H-indazole, which is a heterocyclic compound that has been studied for its potential therapeutic properties. The presence of 5-iodo and 3-methyl groups on the molecule suggests potential biological activity, as these functional groups are often associated with pharmacological effects. The esterification of the carboxylic acid groups may also affect the compound's bioavailability and metabolic stability. Overall, this chemical shows promise for further investigation as a potential drug candidate.

Relevant articles and documents

Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient

As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.

NOVEL INDAZOLE DERIVATIVE

An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.