851961-77-8

Basic information

• Product Name: methyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate
• Synonyms: methyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate
• CAS NO: 851961-77-8
• Molecular Weight: 312.152
• Mol File: 851961-77-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate(851961-77-8)
• EPA Substance Registry System: methyl 2-(4-hydroxy-3,5-dichlorophenylamino)benzoate(851961-77-8)

Safety Data

• Hazardous Substances Data: 851961-77-8(Hazardous Substances Data)

Upstream product

• 618-80-4 2,6-dichloro-4-nitrophenol 
• 848133-03-9 2-(benzyloxy)-1,3-dichloro-5-nitrobenzene 
• 848133-04-0 4-benzyloxy-3,5-dichlorophenylamine 
• 5930-28-9 4-amino-2,6-dichlorophenol 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 851961-76-7 methyl 2-(4-benzyloxy-3,5-dichlorophenylamino)benzoate 

Downstream Products

• 100623-27-6 2-(3,5-dichloro-4-methoxyphenylamino)benzoic acid 
• 851961-79-0 methyl 2-(3,5-dichloro-4-(2-methoxyethoxy)phenylamino)benzoate 
• 851961-78-9 methyl 2-(4-methoxy-3,5-dichlorophenylamino)benzoate 
• 851961-83-6 2-(3,5-dichloro-4-hydroxyphenylamino)benzoic acid 

Relevant articles and documents

AGENTS FOR USE IN THE TREATMENT OF AMYLOIDOSIS

The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agents and medicaments comprising such compounds. The compounds are based on a general structure A-L-B, wherein A is a group of formula (II) or of formula (III): or of formula (IV) or of formula (V) B is a group of formula (III), (IV), or (V), or a group of formula (VI) or a group of formula –R10Z, wherein: Z is selected from -CO2R', -CONR'R'', -SO2R' wherein R' and R'' are independently H or C1-C4 alkyl; and R10 is a C1-C4 alkylene or alkenylene group; and L represents a linker group which is a saturated or unsaturated chain of 5 to 13 carbon atoms.