854107-47-4

Basic information

• Product Name: (Z)-2-isopropylimino-3-phenyl-thiazolidin-4-one
• Synonyms: (Z)-2-isopropylimino-3-phenyl-thiazolidin-4-one
• CAS NO: 854107-47-4
• Molecular Weight: 234.322
• Mol File: 854107-47-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-2-isopropylimino-3-phenyl-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-isopropylimino-3-phenyl-thiazolidin-4-one(854107-47-4)
• EPA Substance Registry System: (Z)-2-isopropylimino-3-phenyl-thiazolidin-4-one(854107-47-4)

Safety Data

• Hazardous Substances Data: 854107-47-4(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 75-31-0 isopropylamine 
• 598-21-0 2-Bromoacetyl bromide 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 1029435-52-6 (Z,Z)-5-(3-chloro-4-hydroxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-28-9 (Z,Z)-5-[3-(2-hydroxyethoxy)benzylidene]-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-24-5 (Z,Z)-5-(4-hydroxymethylbenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-20-1 (Z,Z)-5-(3,4-dihydroxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-25-6 (Z,Z)-5-[4-(2-hydroxyethyl)benzylidene]-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-23-4 (Z,Z)-2-isopropylimino-5-(2-methoxybenzylidene)-3-phenyl-thiazolidin-4-one 
• 1228117-17-6 (Z,Z)-2-isopropylimino-5-(3-methoxybenzylidene)-3-phenyl-thiazolidin-4-one 
• 1228117-21-2 (Z,Z)-2-isopropylimino-5-(2-methylbenzylidene)-3-phenyl-thiazolidin-4-one 
• 1228117-16-5 (Z,Z)-5-(4-bromobenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-18-7 (Z,Z)-5-(3-hydroxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-15-4 (Z,Z)-5-(3,4-dimethoxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-13-2 (Z,Z)-5-(4-hydroxy-3-methoxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 
• 1228117-14-3 (Z,Z)-2-isopropylimino-5-(4-methoxybenzylidene)-3-phenyl-thiazolidin-4-one 
• 1228117-10-9 (Z,Z)-5-(4-hydroxybenzylidene)-2-isopropylimino-3-phenyl-thiazolidin-4-one 

Relevant articles and documents

2-Imino-thiazolidin-4-one derivatives as potent, orally active S1P 1 receptor agonists

Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P conveys its activity through five specific G-protein coupled receptors numbered S1P1 through S1P5. Agonists of the S1P1 receptor block the egress of T-lymphocytes from thymus and lymphoid organs and hold promise for the oral treatment of autoimmune disorders. Here, we report on the discovery and detailed structure-activity relationships of a novel class of S1P1 receptor agonists based on the 2-imino-thiazolidin-4-one scaffold. Compound 8bo (ACT-128800) emerged from this series and is a potent, selective, and orally active S1P1 receptor agonist selected for clinical development. In the rat, maximal reduction of circulating lymphocytes was reached at a dose of 3 mg/kg. The duration of lymphocyte sequestration was dose dependent. At a dose of 100 mg/kg, the effect on lymphocyte counts was fully reversible within less than 36 h. Pharmacokinetic investigation of 8bo in beagle dogs suggests that the compound is suitable for once daily dosing in humans.

5-(BENZ- (Z) -YLIDENE) -THIAZOLIDIN-4-ONE DERIVATIVES AS IMMUNOSUPPRESSANT AGENTS

The invention relates to pharmaceutical compositions containing at least one 5- (benz- (Z) -ylidene-thiazolidin-4-one derivative (I), to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thi