854497-52-2

Basic information

• Product Name: (E)-(S)-2-Methyl-propane-2-sulfinic acid [2-phenyl-ethylidene]-amide
• Synonyms: (E)-(S)-2-Methyl-propane-2-sulfinic acid [2-phenyl-ethylidene]-amide
• CAS NO: 854497-52-2
• Molecular Weight: 223.339
• Mol File: 854497-52-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-(S)-2-Methyl-propane-2-sulfinic acid [2-phenyl-ethylidene]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(S)-2-Methyl-propane-2-sulfinic acid [2-phenyl-ethylidene]-amide(854497-52-2)
• EPA Substance Registry System: (E)-(S)-2-Methyl-propane-2-sulfinic acid [2-phenyl-ethylidene]-amide(854497-52-2)

Safety Data

• Hazardous Substances Data: 854497-52-2(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 343338-28-3 (S)-2-methylpropane-2-sulfinamide 

Downstream Products

• 118867-00-8 (R)-(1-Amino-2-phenylethyl)phosphonsaeure-diethylester 
• 1329450-72-7 (S,R)-5-[(S)-benzyl-(tert-butanesulfinylamino)methyl]furan-2(5H)-one 
• 1329450-75-0 (R,R)-5-[(S)-benzyl-(tert-butanesulfinylamino)methyl]furan-2(5H)-one 
• 1023377-93-6 (S)-2-methyl-propane-2-sulfinic acid ((R)-1-(R)-cyclohexa-2,4-dienyl-2-phenylethyl)-amide 
• 1023378-13-3 C₁₈H₂₅NOS 
• 948843-78-5 C₂₂H₂₇NO₃ 
• 948843-77-4 C₂₂H₂₇NO₃ 
• 948843-56-9 C₂₆H₃₅NO₄S 
• 948843-57-0 C₂₆H₃₅NO₄S 

Relevant articles and documents

KHSO4-mediated condensation reactions of tert-butanesulfinamide with aldehydes. Preparation of tert-butanesulfinyl aldimines

Optically pure tert-butanesulfinyl aldimines 1 were prepared by direct condensation of chiral tert-butanesulfinamide 3 with aldehydes 2 in high yields in the presence of KHSO4. The main advantage of KHSO4 is that it is applicable to the condensation reactions of a variety of aldehydes, including electron deficient and electron rich (hetereo)aromatic aldehydes, as well as aliphatic aldehydes.

Asymmetric vinylogous Mannich reactions: A versatile approach to functionalized heterocycles

Asymmetric vinylogous Mannich reaction (VMR) of 2-(tert- butyldimethylsilyloxy)furan (TBSOF, 1) with (RS)- or (S S)-t-BS-imines (3) furnished 5-aminoalkylbutenolides 7a-k in 75-87% yields with anti/syn ratios ranging from 75:25 to 97:3. Butenolides 7a-f,k were readily converted into substituted lactones 8 and 5 and 6-substituted 5-hydroxypiperidin-2-ones 11a-g, which are, in turn, key intermediates for the synthesis of many bioactive compounds.