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85573-73-5

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85573-73-5 Usage

Uses

[2S-(2α,3β,5α)]-3-(Chloromethyl)-3-methyl-7-oxo-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Diphenylmethyl Ester is an intermediate used in the synthesis of Tazobactam Sodium Salt-15N3 (T010103), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.

Check Digit Verification of cas no

The CAS Registry Mumber 85573-73-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,5,7 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 85573-73:
(7*8)+(6*5)+(5*5)+(4*7)+(3*3)+(2*7)+(1*3)=165
165 % 10 = 5
So 85573-73-5 is a valid CAS Registry Number.

85573-73-5Relevant articles and documents

2 β - Azidomethyl penicillanic acid dibenzoate. Preparation method of tazobactam intermediate and tazobactam

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Paragraph 0080, (2021/11/21)

The invention provides a preparation method of 2 β -azipenicillanic acid dibenzoate, tazobactam intermediate and tazobactam. The preparation method comprises the following steps: carrying out free radical reaction in a solvent by using a reaction raw material comprising a double-sulfur open-loop compound, a stacked nitrogen source and an oxidant to obtain a product system comprising 2 β - azidomethyl penicillanic acid dibenzoate. By radical addition of the carbon-carbon double bonds of the double-sulfur ring-opening compound through the azide free radical, high-efficiency and high-selectivity synthesis of the disulphide ring-opening compound directly to 2 β - azimaapenem naphthenate is successfully realized through intramolecular radical substitution. Further, 2 β - azidomethyl penicillanic acid dibenzoate is taken as a key intermediate for synthesizing tazobactam, the yield of tazobactam is improved, and the cost is reduced.

Preparation technologies of tazobactam acid and tazobactam diphenylmethyl ester and application

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Paragraph 0026; 0027; 0033; 0035; 0037, (2018/07/07)

The invention relates to preparation technologies of tazobactam acid and tazobactam diphenylmethyl ester and application. A preparation route is as follows: with methylbenzene, 2-mercaptobenzothiazoleand a debrominated product as starting materials, the tazobactam diphenylmethyl ester is prepared after a ring opening reaction, a chlorination reaction, a condensation reaction and a double oxidation reaction, then the tazobactam diphenylmethyl ester is transformed into the tazobactam acid after a deprotection reaction; a preparation method in the scheme is improved on the basis of an iodinationreaction in the prior art, and the chlorination reaction is introduced, so that the reaction quality is optimized, the product purity is improved, and use of toxic, harmful, flammable and explosive substances in the reaction process is reduced, and thus the reaction is more environment-friendly; the product yield can be as high as 98-99.92%, and the preparation cost is also lower than that of thepreparation technology in the prior art.

Synthesis of penicillin derivatives and study of their cytotoxic properties

Veinberg,Bokaldere,Dikovskaya,Vorona,Mucel',Kazhoka,Turovskis,Shestakova,Kanepe,Domracheva,Lukevics

, p. 1266 - 1275 (2007/10/03)

By the interaction of heterocyclic thiols with sulforides of 6,6-dihydro- and 6α-chloropenicillanates, derivatives of 4-heteryldithio-2-azetidinones have been synthesized, as well as products of their cyclization to form 2β-heterylthiomethyl-and 2β-halorn

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