856767-09-4

Basic information

• Product Name: 4-broMo-2-fluoro-6-Methoxybenzaldehyde
• Synonyms: 4-broMo-2-fluoro-6-Methoxybenzaldehyde;Benzaldehyde, 4-broMo-2-fluoro-6-Methoxy-
• CAS NO: 856767-09-4
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.0344432
• Mol File: 856767-09-4.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 270.8±40.0 °C(Predicted)
• Appearance: /
• Density: 1.601±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-broMo-2-fluoro-6-Methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-2-fluoro-6-Methoxybenzaldehyde(856767-09-4)
• EPA Substance Registry System: 4-broMo-2-fluoro-6-Methoxybenzaldehyde(856767-09-4)

Safety Data

• Hazardous Substances Data: 856767-09-4(Hazardous Substances Data)

Usage

Uses

4-Bromo-2-fluoro-6-methoxybenzaldehyde is used in preparation of dihydropyrimidines as Brd9 bifunctional degraders for treatment and prophylaxis of Brd9-mediated diseases.

Upstream product

• 67-56-1 methanol 
• 537013-51-7 4-bromo-2,6-difluorobenzaldehyde 
• 74-88-4 methyl iodide 
• 123843-67-4 4-bromo-2,6-difluorobenzonitrile 
• 124-41-4 sodium methylate 
• 461-96-1 3,5-difluorobromobenzene 
• 457051-15-9 4-bromo-2-fluoro-6-methoxy-benzonitrile 
• 29578-39-0 1-bromo-3-fluoro-5-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 885519-21-1 6-bromo-4-methoxy-1H-indazole 
• 885521-13-1 methyl 4-methoxy-1H-indazole-6-carboxylate 
• 1245215-47-7 methyl 4-methoxy-2-methyl-2H-indazole-6-carboxylate 
• 1245215-48-8 methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate 

Relevant articles and documents

Aryl imidazole derivative and application thereof

The invention relates to an aryl imidazole derivative and application thereof. The aryl imidazole derivative is a compound shown as a formula (I) in the description or pharmaceutically acceptable salt thereof. The invention also discloses application of the aryl imidazole derivative in preparation of drugs for treating cancers. The invention further discloses application of the aryl imidazole derivative in preparation of drugs for treating diseases caused by EGFR mutation.

METHODS AND COMPOUNDS FOR TREATING DISORDERS

The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

PYRAZOLYL-SUBSTITUTED HETEROARYLS AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted heteroaryls of formula 1 or of formula 1' wherein A is either N or CH, wherein R2 is selected from the group consisting of -C1-3-alkyl, -C1-3-haloalkyl, F, Br, CI, wherein Y is selected from -O- or -CH2-, and wherein R3 is defined as in claim 1, and the pharmaceutically acceptable salts thereof, and the use of these aforementioned compounds for the treatment of diseases such as asthma, COPD, allergic rhinitis, allergic dermatitis, lupus erythematodes, lupus nephritis and rheumatoid arthritis.