858116-66-2

Basic information

• Product Name: 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE;5-Bromo-1-triisopropylsilanyl-7-azaindole;5-broMo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine;5-BroMo-1-triisopropylsil...;5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE-2;5-bromo-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine;(5-Bromopyrrolo[2,3-b]pyridin-1-yl)-triisopropyl-silane
• CAS NO: 858116-66-2
• Molecular Formula: C₁₆H₂₅BrN₂Si
• Molecular Weight: 353.3726
• Mol File: 858116-66-2.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 333.7°C at 760 mmHg
• Flash Point: 155.6°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: 2-8°C
• PKA: 2.87±0.30(Predicted)
• CAS DataBase Reference: 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE(858116-66-2)
• EPA Substance Registry System: 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE(858116-66-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 858116-66-2(Hazardous Substances Data)

Usage

General Description

5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE is a chemical compound with a molecular formula C15H24BrN2Si. It is a brominated pyrrolopyridine derivative that contains a triisopropylsilyl group. 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE is commonly used in organic synthesis and medicinal chemistry to create new molecular entities with potential biological activity. Its unique structure makes it an attractive building block for the development of pharmaceuticals and agrochemicals. Additionally, the triisopropylsilyl group can serve as a protecting group for sensitive functional groups, making it a versatile tool for the synthesis of complex organic molecules. Overall, 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE is a valuable chemical compound with a wide range of applications in various fields of chemistry.

InChI:InChI=1/C16H25BrN2Si/c1-11(2)20(12(3)4,13(5)6)19-8-7-14-9-15(17)10-18-16(14)19/h7-13H,1-6H3

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 918523-66-7 5-methyl-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine 
• 1235865-75-4 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-fluorobenzoic acid methyl ester 
• 1235865-76-5 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid methyl ester 
• 1235865-77-6 [2-((1H-pyrrolo [2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid] 
• 1257044-40-8 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide 
• 1379647-80-9 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide sulfate 
• 900514-10-5 5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 868387-37-5 5‐fluoro-1-triisopropylsilylpyrrolo[2,3‐b]pyridine 
• 1257044-57-7 methyl (2-((1H-pyrrole[2,3-b]pyridin-5-yl)oxy)-4-(piperazin-1-yl))benzoate 
• 1093759-49-9 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 
• 1386986-43-1 1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine-5-deuterocarbaldehyde 
• 1386986-48-6 (6-bromo-5-trideuteromethoxy-dideuteromethyl-pyrrolo[2,3-b]pyridin-1-yl)-phenyl-methanone 
• 685514-01-6 1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol 
• 918523-63-4 2-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-propan-2-ol 

Relevant articles and documents

Novel BCL-2/BCL-XL inhibitor, pharmaceutical composition and application

The invention relates to a compound for inhibiting the activity of Bcl-2/BCL-XL anti-apoptotic protein, a composition containing the compound and application of the compound serving as a synthetic drug, in particular to application of the compound serving as a drug for synthesizing a Bcl-2/BCL-XL anti-apoptotic protein inhibitor and application of the compound to cancer.

Solid dispersions containing an apoptosis-inducing agent

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF

Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.