85862-68-6

Basic information

• Product Name: Benzene, 1-azido-3,5-dimethoxy-
• CAS NO: 85862-68-6
• Molecular Formula: C8H9N3O2
• Molecular Weight: 179.178
• Mol File: 85862-68-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzene, 1-azido-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-azido-3,5-dimethoxy-(85862-68-6)
• EPA Substance Registry System: Benzene, 1-azido-3,5-dimethoxy-(85862-68-6)

Safety Data

• Hazardous Substances Data: 85862-68-6(Hazardous Substances Data)

Upstream product

• 192182-54-0 3,5-dimethoxyphenylboronic acid 
• 365564-07-4 3,5-dimethoxyphenylboronic acid pinacol ester 
• 151-10-0 1,3-Dimethoxybenzene 
• 86988-56-9 3,5-Dimethoxy-benzenediazonium; chloride 
• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 1380227-20-2 8-(1-(3,5-dimethoxyphenyl)-1H-1,2,3-triazol-4-yl)-2-morpholinoquinolin-4(1H)-one 

Relevant articles and documents

Quinazoline substituted 1, 2, 3-triazole derivative as well as pharmaceutical composition, preparation method and application thereof

The invention discloses a quinazoline substituted 1, 2, 3-triazole derivative, the derivative is shown as a general formula (I), and the definition of each substituent group is shown in the specification. In addition, the invention also discloses a preparation method of the compound. The compound shown in the general formula (I) has an inhibiting effect on proliferation of tumor cells, also has an inhibiting effect on proliferation of human colon cancer (HCT-116) and human lung cancer cell strain (A549) cells, and can be used as an antitumor drug.

A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including14C and11C, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.

Synthesis and Antitrypanosomal Activity of 1,4-Disubstituted Triazole Compounds Based on a 2-Nitroimidazole Scaffold: a Structure-Activity Relationship Study

Chagas disease affects 6–8 million people worldwide, remaining a public health concern. Toxicity, several adverse effects and inefficiency in the chronic stage of the disease are the major challenges regarding the available treatment protocols. This work involved the synthesis of twenty-two 1,4-disubstituted-1,2,3-triazole analogues of benznidazole (BZN), by using a click chemistry strategy. Analogues were obtained in moderate to good yields (40-97 %). Antitrypanosomal activity was evaluated against the amastigote forms of Trypanosoma cruzi. Compound 8 a (4-(2-nitro-1H-imidazol-1-yl)methyl)-1-phenyl-1H-1,2,3-triazole) without substituents on phenyl ring showed similar biological activity to BZN (IC50=3.0 μM, SI>65.3), with an IC50=3.1 μM and SI>64.5. Compound 8 o (3,4-di-OCH3?Ph) with IC50 = 0.65 μM was five-fold more active than BZN, and showed an excellent selectivity index (SI>307.7). Compound 8 v (3-NO2, 4-CH3?Ph) with IC50=1.2 μM and relevant SI>166.7, also exhibited higher activity than BZN. SAR analysis exhibited a pattern regarding antitrypanosomal activity relative to BZN, in compounds with electron-withdrawing groups (Hammett σ+) at position 3, and electron-donating groups (Hammett σ-) at position 4, as observed in 8 o and 8 v. Further research might explore in vivo antitrypanosomal activity of promising analogues 8 a, 8 o, and 8 v. Overall, this study indicates that approaches such as the bioisosteric replacement of amide group by 1,2,3-triazole ring, the use of click chemistry as a synthesis strategy, and design tools like Craig-plot and Topliss tree are promising alternatives to drug discovery.