861218-13-5

Basic information

• Product Name: 4-(2-fluoro-phenyl)-benzo[b]thiophene-2-carboxylic acid methyl ester
• CAS NO: 861218-13-5
• Molecular Weight: 286.327
• Mol File: 861218-13-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-fluoro-phenyl)-benzo[b]thiophene-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluoro-phenyl)-benzo[b]thiophene-2-carboxylic acid methyl ester(861218-13-5)
• EPA Substance Registry System: 4-(2-fluoro-phenyl)-benzo[b]thiophene-2-carboxylic acid methyl ester(861218-13-5)

Safety Data

• Hazardous Substances Data: 861218-13-5(Hazardous Substances Data)

Upstream product

• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 1993-03-9 o-fluorophenylboronic acid 
• 360575-29-7 methyl 4-bromobenzo[b]thiophene-2-carboxylate 
• 1073-06-9 3-fluorobromobenzene 

Relevant articles and documents

4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na +/H+ exchanger isoform-1 (NHE-1) inhibitors

A series of 4-substituted (benzo[b]thiophene-2-carbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardioprotective efficacy both in vitro and in vivo. Several analogs exhibited a strong inhibition on NHE-1, and which was generally well correlated with their cardioprotective efficacy. Especially the 4-nitro 20 and cyano 50 compounds excellently improved the cardiac function and reduced infarct size against ischemia/reperfusion injury.