86382-78-7Relevant articles and documents
Propafenone analogue with additional H-bond acceptor group shows increased inhibitory activity on P-glycoprotein
Cseke, Anna,Decker, Simon,Ecker, Gerhard F.,Jain, Sankalp,Schwarz, Theresa,Urban, Ernst,Vogl, Kerstin
, (2020)
P-glycoprotein (P-gp) is an ATP-dependent efflux pump that has a marked impact on the absorption, distribution, and excretion of therapeutic drugs. As P-gp inhibition can result in drug–drug interactions and altered drug bioavailability, identifying molec