863868-32-0Relevant articles and documents
COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES
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Paragraph 0097-0098, (2013/05/21)
The invention relates to certain compounds or pharmaceutically acceptable salts, solvates, clathrates, or prodrugs thereof, that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders
Process for producing cyano substituted arene boranes and compounds
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Page/Page column 12, (2008/06/13)
A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
Sterically directed functionalization of aromatic C-H bonds: Selective borylation ortho to cyano groups in arenes and heterocycles
Chotana, Ghayoor A.,Rak, Michael A.,Smith, Milton R.
, p. 10539 - 10544 (2007/10/03)
Ir-catalyzed borylations of 4-substituted benzonitriles are described. In contrast to electrophilic aromatic substitutions and directed ortho metalations, C-H activation/borylation enables functionalization at the 2-position, adjacent to the cyano group, when the 4-subsitutent is larger than cyano. When an excess of borane reagent is used, diborylation can be achieved with a single regioisomer being formed in certain cases. Extension of sterically directed borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.