86541-79-9Relevant articles and documents
AG-08 MOLECULE THAT IS A SAPOGENOL DERIVATIVE EXHIBITNG CYTOTOXIC EFFECTS BY ACTIVATING THE NECROSIS PATHWAY AND SYNTHESIS METHOD THEREOF
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Sheet 1, (2020/11/13)
The invention is related to an AG-08 coded novel structured molecule having cytotoxic features against cancer cells. The aim of the invention is to primarily synthesize the astragenol (AG) molecule from cycloastragenol (CA) and then from here, the cytotoxic molecule coded AG-08 which enables to kill cancer cells via a pathway that is non-apoptotic as a difference from the compounds that exhibit traditional anticancer activity.
Saponin and Sapogenol. XXXIV. Chemical constituents of Astragali Radix, the root of Astragalus membranaceus Bunge. (1) Cycloastragenol, the 9,19-cyclolanostane-type aglycone of astragalosides, artifact aglycone astragenol
Kitagawa,Wang,Takagi,et al.
, p. 689 - 697 (2007/10/02)
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TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. II. THE STRUCTURE OF CYCLOSIEVERSIGENIN
Svechnikova, A. N.,Umarova, R. U.,Gorovits, M. B.,Seitanudi, K. L.,Rashkes, Ya. V.,et al
, p. 60 - 67 (2007/10/02)
The bitter plant Astragalus sieversianus has yielded a new isoprenoid cyclosieversigenin the structure of which has been established on the basis of spectral characteristics and chemical transformations as 20(S),24(R)-epoxycycloartane-3β,6α,16β,25-tetraol.