86770-69-6

Basic information

• Product Name: Azido-PEG6
• Synonyms: Azido-PEG6;Azido-PEG6-alcohol;N3-PEG6-OH
• CAS NO: 86770-69-6
• Molecular Formula: C₁₂H₂₅N₃O₆
• Molecular Weight: 307.3434
• Mol File: 86770-69-6.mol
• Article Data: 62

Chemical Properties

• Appearance: /
• Solubility: Soluble in Water, DMSO, DCM, DMF
• CAS DataBase Reference: Azido-PEG6(CAS DataBase Reference)
• NIST Chemistry Reference: Azido-PEG6(86770-69-6)
• EPA Substance Registry System: Azido-PEG6(86770-69-6)

Safety Data

• Hazardous Substances Data: 86770-69-6(Hazardous Substances Data)

Usage

Description

Azido-PEG6-alcohol, a water soluble reagent, consist of an azide and a terminal hydroxyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Upstream product

• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 69502-33-6 2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 
• 77544-68-4 8-tosyloxy-3,6-dioxaoctanol 
• 139115-90-5 2-(2-azidoethoxy)ethanol 
• 39160-70-8 3,6,9,12,15,18-hexaoxa-1-octadecyl amine 
• 136399-07-0 17-iodo-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 28746-78-3 17-chloro-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 2615-15-8 pentaethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 1352550-66-3 17-azido-3,6,9,12,15-pentaoxaheptadecyl 2-chloroacetate 
• 112-60-7 Tetraethylene glycol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 

Downstream Products

• 1264015-86-2 3'-(4{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoylamino)-2,2'-bipyridine-3-amine 
• 1264015-76-0 2-{2-[2-(2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy)ethoxy]ethoxy}ethyl p-tosylate 
• 1264015-79-3 methyl 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoate 
• 1264015-81-7 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoic acid 
• 1264015-83-9 C₄₆H₈₂ClNO₂₁ 
• 1402411-90-8 17-azido-1-bromo-3,6,9,12,15-pentaoxaheptadecane 
• 1432887-55-2 C₄₇H₅₉BF₂N₆O₇ 
• 1432887-71-2 C₅₆H₆₄BF₂N₇O₇ 
• 1448451-77-1 C₃₅H₄₄N₄O₁₃ 
• 1448451-72-6 tert-butyl 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-oate 
• 1104083-46-6 20-amino-3,6,9,12,15,18-hexaoxaicosanoic acid 
• 1448451-78-2 C₂₉H₄₄N₄O₁₂ 
• 1448451-79-3 C₃₁H₄₅F₃N₂O₁₃ 
• 1448451-80-6 C₃₁H₄₇F₃N₂O₁₃ 

Relevant articles and documents

THERAPEUTIC CURE-PRO COMPOUNDS FOR TARGETED DEGRADATION OF BET DOMAIN PROTEINS, AND METHODS OF MAKING AND USING THEM

The present application is directed to a therapeutically useful compound, comprised of two monomers that are linked to each other through two or more reversible covalent bonds. Each monomer is a polyfunctionalized molecule comprising a bioorthogonal linker element and ligand or pharmacophore, wherein the linker and ligand/pharmacophore are covalently coupled to each other either directly or through an optional connector moiety.

Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase

PI3K kinase plays an important role in regulating key processes in cells, such as cell growth, metabolism, proliferation, and apoptosis. The overexpression of PI3K kinase exists in many cancers. The proteolytic target chimera (PROTAC) technology is a new technology that uses the ubiquitin–proteasome system to degrade a given target protein. It has been described that CRBN-based PROTAC targets the degradation of PI3K kinase. However, PROTAC based on VHL has not been reported yet. Here, we connected the previously obtained highly active PI3K inhibitor to the VHL ligand through different small molecules, and obtained a series of PROTAC molecules targeting PI3K kinase. Obtain the most active compound through screening. It provides evidence for the feasibility of PROTAC technology to recruit VHL E3 ligase in PI3K kinase.

Supramolecular compound nano-carrier as well as preparation method and application thereof

The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.